Fig. 11From: Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans Model for SING formation. Unstressed cells experience a healthy protein homeostasis. When cells are exposed to stressors that induce protein misfolding, the ubiquitin system adds K48-linked ubiquitin chains to the misfolded proteins. Ubiquitinated proteins and proteasomes localize to SINGs in the nucleusBack to article page