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  1. Research article

    Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila

    In Drosophila early post-meiotic spermatids, mitochondria undergo dramatic shaping into the Nebenkern, a spherical body with complex internal structure that contains two interwrapped giant mitochondrial derivativ...

    Eric M. Sawyer, Elizabeth C. Brunner, Yihharn Hwang, Lauren E. Ivey, Olivia Brown, Megan Bannon, Dennis Akrobetu, Kelsey E. Sheaffer, Oshauna Morgan, Conroy O. Field, Nishita Suresh, M. Grace Gordon, E. Taylor Gunnell, Lindsay A. Regruto, Cricket G. Wood, Margaret T. Fuller…

    BMC Cell Biology 2017 18:16

    Published on: 23 March 2017

  2. Research article

    Mesenchymal stem cells and myoblast differentiation under HGF and IGF-1 stimulation for 3D skeletal muscle tissue engineering

    Volumetric muscle loss caused by trauma or after tumour surgery exceeds the natural regeneration capacity of skeletal muscle. Hence, the future goal of tissue engineering (TE) is the replacement and repair of ...

    R. Witt, A. Weigand, A. M. Boos, A. Cai, D. Dippold, A. R. Boccaccini, D. W. Schubert, M. Hardt, C. Lange, A. Arkudas, R. E. Horch and J. P. Beier

    BMC Cell Biology 2017 18:15

    Published on: 28 February 2017

  3. Research article

    Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties

    Cell-based therapy is a treatment method in tendon injuries. Bone morphogenic protein 12 (BMP-12) possesses tenogenic activity and was proposed as a differentiating factor for stem cells directed to transplant...

    Weronika Zarychta-Wiśniewska, Anna Burdzinska, Agnieszka Kulesza, Kamila Gala, Beata Kaleta, Katarzyna Zielniok, Katarzyna Siennicka, Marek Sabat and Leszek Paczek

    BMC Cell Biology 2017 18:13

    Published on: 18 February 2017

  4. Research article

    Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities

    Dental pulp stem cells (DPSCs) are increasingly being recognized as a viable cell source for regenerative medicine. Although significant variations in their ex vivo expansion are well-established, DPSC prolife...

    Amr Alraies, Nadia Y. A. Alaidaroos, Rachel J. Waddington, Ryan Moseley and Alastair J. Sloan

    BMC Cell Biology 2017 18:12

    Published on: 2 February 2017

  5. Research article

    Nuclear and structural dynamics during the establishment of a specialized effector-secreting cell by Magnaporthe oryzae in living rice cells

    To cause an economically important blast disease on rice, the filamentous fungus Magnaporthe oryzae forms a specialized infection structure, called an appressorium, to penetrate host cells. Once inside host cells...

    Emma N. Shipman, Kiersun Jones, Cory B. Jenkinson, Dong Won Kim, Jie Zhu and Chang Hyun Khang

    BMC Cell Biology 2017 18:11

    Published on: 26 January 2017

  6. Research

    Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins

    Obstructive sleep apnea has been linked to the development of heart disease and arrhythmias, including atrial fibrillation. Since altered conduction through gap junction channels can contribute to the pathogen...

    Joanna Gemel, Zihan Su, Alex Gileles-Hillel, Abdelnaby Khalyfa, David Gozal and Eric C. Beyer

    BMC Cell Biology 2017 18(Suppl 1):7

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  7. Research article

    miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway

    MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regul...

    Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang and Lin Liu

    BMC Cell Biology 2017 18:9

    Published on: 17 January 2017

  8. Review

    Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels

    This review comes after the International Gap Junction Conference (IGJC 2015) and describes the current knowledge on the function of the specific motifs of connexins in the regulation of the formation of gap j...

    Thomas Desplantez

    BMC Cell Biology 2017 18(Suppl 1):3

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  9. Review

    Focus on lens connexins

    The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epit...

    Viviana M. Berthoud and Anaclet Ngezahayo

    BMC Cell Biology 2017 18(Suppl 1):6

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  10. Review

    Pannexin channel and connexin hemichannel expression in vascular function and inflammation

    Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins or panne...

    Daniela Begandt, Miranda E Good, Alex S. Keller, Leon J. DeLalio, Carol Rowley, Brant E. Isakson and Xavier F. Figueroa

    BMC Cell Biology 2017 18(Suppl 1):2

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  11. Review

    Accessing gap-junction channel structure-function relationships through molecular modeling and simulations

    Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells. These channels allow intercellular transfer of molecules up to ~1 kDa, including water, ions and other meta...

    F. Villanelo, Y. Escalona, C. Pareja-Barrueto, J. A. Garate, I. M. Skerrett and T. Perez-Acle

    BMC Cell Biology 2017 18(Suppl 1):5

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  12. Review

    Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease

    Gap junctions are unique membrane channels that play a significant role in intercellular communication in the developing and mature central nervous system (CNS). These channels are composed of connexin protein...

    Andrei B. Belousov, Joseph D. Fontes, Moises Freitas-Andrade and Christian C. Naus

    BMC Cell Biology 2017 18(Suppl 1):4

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  13. Research article

    Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression

    Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural...

    Elizabeth R. Smith, Yue Meng, Robert Moore, Jeffrey D. Tse, Arn G. Xu and Xiang-Xi Xu

    BMC Cell Biology 2017 18:8

    Published on: 14 January 2017

  14. Methodology article

    Hierarchical imaging: a new concept for targeted imaging of large volumes from cells to tissues

    Imaging large volumes such as entire cells or small model organisms at nanoscale resolution seemed an unrealistic, rather tedious task so far. Now, technical advances have lead to several electron microscopy (...

    Irene Wacker, Waldemar Spomer, Andreas Hofmann, Marlene Thaler, Stefan Hillmer, Ulrich Gengenbach and Rasmus R. Schröder

    BMC Cell Biology 2016 17:38

    Published on: 12 December 2016

  15. Research article

    Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis

    The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is exte...

    Callinice D. Capo-chichi, Toni M. Yeasky, Elizabeth R. Smith and Xiang-Xi Xu

    BMC Cell Biology 2016 17:37

    Published on: 22 November 2016

    The Erratum to this article has been published in BMC Cell Biology 2017 18:1

  16. Research article

    Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells

    To explore the relationship between spatial genome organization and gene expression in the interphase nucleus, we used a genomic imprinting model, which offers parental-specific gene expression. Using 3D FISH ...

    Yvette Lahbib-Mansais, Harmonie Barasc, Maria Marti-Marimon, Florence Mompart, Eddie Iannuccelli, David Robelin, Juliette Riquet and Martine Yerle-Bouissou

    BMC Cell Biology 2016 17:35

    Published on: 1 October 2016

  17. Research

    High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division

    Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. ...

    David Dickerson, Marek Gierliński, Vijender Singh, Etsushi Kitamura, Graeme Ball, Tomoyuki U. Tanaka and Tom Owen-Hughes

    BMC Cell Biology 2016 17:33

    Published on: 8 September 2016

  18. Research article

    A specific FMNL2 isoform is up-regulated in invasive cells

    Formins are a highly conserved family of cytoskeletal remodeling proteins. A growing body of evidence suggests that formins play key roles in the progression and spread of a variety of cancers. There are 15 hu...

    Christine Péladeau, Allan Heibein, Melissa T. Maltez, Sarah J. Copeland and John W. Copeland

    BMC Cell Biology 2016 17:32

    Published on: 30 August 2016

  19. Methodology article

    Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction

    Karyotypic integrity is essential for the successful germline transmission of alleles mutated in embryonic stem (ES) cells. Classical methods for the identification of aneuploidy involve cytological analyses t...

    Gemma F. Codner, Loic Lindner, Adam Caulder, Marie Wattenhofer-Donzé, Adam Radage, Annelyse Mertz, Benjamin Eisenmann, Joffrey Mianné, Edward P. Evans, Colin V. Beechey, Martin D. Fray, Marie-Christine Birling, Yann Hérault, Guillaume Pavlovic and Lydia Teboul

    BMC Cell Biology 2016 17:30

    Published on: 5 August 2016

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