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  1. Research article

    Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells

    Endophytes have proven to be an invaluable resource of chemically diverse secondary metabolites that act as excellent lead compounds for anticancer drug discovery. Here we report the promising cytotoxic effect...

    Mytre Koul, Ashok Kumar, Ramesh Deshidi, Vishal Sharma, Rachna D. Singh, Jasvinder Singh, Parduman Raj Sharma, Bhawal Ali Shah, Sundeep Jaglan and Shashank Singh

    BMC Cell Biology 2017 18:26

    Published on: 20 July 2017

  2. Research article

    The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1

    Staufen2 (STAU2) is an RNA-binding protein involved in the post-transcriptional regulation of gene expression. This protein was shown to be required for organ formation and cell differentiation. Although STAU2...

    Rémy Beaujois, Elizabeth Ottoni, Xin Zhang, Christina Gagnon, Sami HSine, Stéphanie Mollet, Wildriss Viranaicken and Luc DesGroseillers

    BMC Cell Biology 2017 18:25

    Published on: 14 July 2017

  3. Research article

    External magnetic field promotes homing of magnetized stem cells following subcutaneous injection

    Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to self-renew and migrate to sites of pathology. In vivo tracking of MSCs provides insights into both, the underlying mechanism...

    Yu Meng, Changzhen Shi, Bo Hu, Jian Gong, Xing Zhong, Xueyin Lin, Xinju Zhang, Jun Liu, Cong Liu and Hao Xu

    BMC Cell Biology 2017 18:24

    Published on: 26 May 2017

  4. Research article

    Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation

    Biomaterials are widely used to regenerate or substitute bone tissue. In order to evaluate their potential use for clinical applications, these need to be tested and evaluated in vitro with cell culture models...

    Raquel Núñez-Toldrà, Ester Martínez-Sarrà, Carlos Gil-Recio, Miguel Ángel Carrasco, Ashraf Al Madhoun, Sheyla Montori and Maher Atari

    BMC Cell Biology 2017 18:21

    Published on: 21 April 2017

  5. Research article

    Loss of pericyte smoothened activity in mice with genetic deficiency of leptin

    Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy avail...

    Guanhua Xie, Marzena Swiderska-Syn, Mark L. Jewell, Mariana Verdelho Machado, Gregory A. Michelotti, Richard T. Premont and Anna Mae Diehl

    BMC Cell Biology 2017 18:20

    Published on: 20 April 2017

  6. Research article

    Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts

    External root resorption, commonly starting from cementum, is a severe side effect of orthodontic treatment. In this pathological process and repairing course followed, cementoblasts play a significant role. P...

    Yuyu Li, Zhiai Hu, Chenchen Zhou, Yang Xu, Li Huang, Xin Wang and Shujuan Zou

    BMC Cell Biology 2017 18:19

    Published on: 20 April 2017

  7. Research article

    Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells

    The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be...

    Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning and Stian Knappskog

    BMC Cell Biology 2017 18:17

    Published on: 17 April 2017

  8. Research article

    Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila

    In Drosophila early post-meiotic spermatids, mitochondria undergo dramatic shaping into the Nebenkern, a spherical body with complex internal structure that contains two interwrapped giant mitochondrial derivativ...

    Eric M. Sawyer, Elizabeth C. Brunner, Yihharn Hwang, Lauren E. Ivey, Olivia Brown, Megan Bannon, Dennis Akrobetu, Kelsey E. Sheaffer, Oshauna Morgan, Conroy O. Field, Nishita Suresh, M. Grace Gordon, E. Taylor Gunnell, Lindsay A. Regruto, Cricket G. Wood, Margaret T. Fuller…

    BMC Cell Biology 2017 18:16

    Published on: 23 March 2017

  9. Research article

    Mesenchymal stem cells and myoblast differentiation under HGF and IGF-1 stimulation for 3D skeletal muscle tissue engineering

    Volumetric muscle loss caused by trauma or after tumour surgery exceeds the natural regeneration capacity of skeletal muscle. Hence, the future goal of tissue engineering (TE) is the replacement and repair of ...

    R. Witt, A. Weigand, A. M. Boos, A. Cai, D. Dippold, A. R. Boccaccini, D. W. Schubert, M. Hardt, C. Lange, A. Arkudas, R. E. Horch and J. P. Beier

    BMC Cell Biology 2017 18:15

    Published on: 28 February 2017

  10. Research article

    Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties

    Cell-based therapy is a treatment method in tendon injuries. Bone morphogenic protein 12 (BMP-12) possesses tenogenic activity and was proposed as a differentiating factor for stem cells directed to transplant...

    Weronika Zarychta-Wiśniewska, Anna Burdzinska, Agnieszka Kulesza, Kamila Gala, Beata Kaleta, Katarzyna Zielniok, Katarzyna Siennicka, Marek Sabat and Leszek Paczek

    BMC Cell Biology 2017 18:13

    Published on: 18 February 2017

  11. Research article

    Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities

    Dental pulp stem cells (DPSCs) are increasingly being recognized as a viable cell source for regenerative medicine. Although significant variations in their ex vivo expansion are well-established, DPSC prolife...

    Amr Alraies, Nadia Y. A. Alaidaroos, Rachel J. Waddington, Ryan Moseley and Alastair J. Sloan

    BMC Cell Biology 2017 18:12

    Published on: 2 February 2017

  12. Research article

    Nuclear and structural dynamics during the establishment of a specialized effector-secreting cell by Magnaporthe oryzae in living rice cells

    To cause an economically important blast disease on rice, the filamentous fungus Magnaporthe oryzae forms a specialized infection structure, called an appressorium, to penetrate host cells. Once inside host cells...

    Emma N. Shipman, Kiersun Jones, Cory B. Jenkinson, Dong Won Kim, Jie Zhu and Chang Hyun Khang

    BMC Cell Biology 2017 18:11

    Published on: 26 January 2017

  13. Research

    Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins

    Obstructive sleep apnea has been linked to the development of heart disease and arrhythmias, including atrial fibrillation. Since altered conduction through gap junction channels can contribute to the pathogen...

    Joanna Gemel, Zihan Su, Alex Gileles-Hillel, Abdelnaby Khalyfa, David Gozal and Eric C. Beyer

    BMC Cell Biology 2017 18(Suppl 1):7

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  14. Research article

    miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway

    MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regul...

    Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang and Lin Liu

    BMC Cell Biology 2017 18:9

    Published on: 17 January 2017

  15. Review

    Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels

    This review comes after the International Gap Junction Conference (IGJC 2015) and describes the current knowledge on the function of the specific motifs of connexins in the regulation of the formation of gap j...

    Thomas Desplantez

    BMC Cell Biology 2017 18(Suppl 1):3

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  16. Review

    Focus on lens connexins

    The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epit...

    Viviana M. Berthoud and Anaclet Ngezahayo

    BMC Cell Biology 2017 18(Suppl 1):6

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  17. Review

    Pannexin channel and connexin hemichannel expression in vascular function and inflammation

    Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins or panne...

    Daniela Begandt, Miranda E Good, Alex S. Keller, Leon J. DeLalio, Carol Rowley, Brant E. Isakson and Xavier F. Figueroa

    BMC Cell Biology 2017 18(Suppl 1):2

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  18. Review

    Accessing gap-junction channel structure-function relationships through molecular modeling and simulations

    Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells. These channels allow intercellular transfer of molecules up to ~1 kDa, including water, ions and other meta...

    F. Villanelo, Y. Escalona, C. Pareja-Barrueto, J. A. Garate, I. M. Skerrett and T. Perez-Acle

    BMC Cell Biology 2017 18(Suppl 1):5

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  19. Review

    Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease

    Gap junctions are unique membrane channels that play a significant role in intercellular communication in the developing and mature central nervous system (CNS). These channels are composed of connexin protein...

    Andrei B. Belousov, Joseph D. Fontes, Moises Freitas-Andrade and Christian C. Naus

    BMC Cell Biology 2017 18(Suppl 1):4

    Published on: 17 January 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  20. Research article

    Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression

    Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural...

    Elizabeth R. Smith, Yue Meng, Robert Moore, Jeffrey D. Tse, Arn G. Xu and Xiang-Xi Xu

    BMC Cell Biology 2017 18:8

    Published on: 14 January 2017

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