Fig. 6From: Spatiotemporal patterns of sortilin and SorCS2 localization during organ developmentSortilin is expressed in the tubular system of the developing metanephros. Immunohistofluorescence was performed on sagittal sections (10 μm) of embryos on embryonic day E13.5 (a, a’), E15.5 (b, b’) and E17.5 (c). Sortilin shows marked apical expression in ureteric branches and a portion of the metanephric tubular system. This expression becomes more prominent from E13.5-E15.5 and remains stable at E17.5. Green channel is sortilin, red channel is Calbindin-D28K and blue channel is Hoechst nuclear stain. Scale bars = 50 μm. Ki, kidney; Me, metanephric mesenchyme; Sb, S-shaped body Ub, ureteric branchBack to article page