Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors

Table 7 FOXO and NFκB regulated genes.

	Growth Factor/Receptor or Cytokine	Transcription	Proliferation	Apoptosis	References
FOXO Target Genes
*ATROGIN-1*					[51]
*BCL6*		+		+	[49, 50, 80]
*BTG1*			+		[48, 81]
*CCNG2*			+		[41,46, 47]
DDIT3/CHOP		+	+	+	[36, 82]
KIF1B
KLF6		+	+		[83]
KLHL24
TXNIP				+	[84]
ZBTB1
NFκB Target Genes
AMIGO2				+	[85]
BDNF	+		+	+	[86]
*BIRC3/cIAP2*				+	[54, 87]
*CCL2*	+			+	[55, 88]
*CCND1*			+		[56]
*EDN1-site I*	+		+	+	[57, 89, 90]
EDN1-site II	+		+	+	[89, 90]
F3-site I
*F3-site II*					[58]
FST	+		+		[91]
G0S2			+		[92]
*GABPB2*					[53]
IGFBP5	+		+	+	[93, 94]
*IL7R-site II*	+		+	+	[59, 95]
IL7R-site I	+		+	+	[95]
MAT2A-site I
*MAT2A-site II*					[60]
*PLAU*			+	+	[61, 96]
*PTX3*					[62]
RGS20
STC2
TNFRSF11B/osteoprotegerin				+	[40]

All PI 3-kinase regulated genes containing upstream binding sites for either FOXO or NFκB are listed. Genes containing a previously reported FOXO or NFκB binding site, and the relevant reference, are in bold. The biological activity of each gene, as it pertains to growth factor/receptor or cytokine, transcription, proliferation, and apoptosis, is indicated along with references for these activities.

ISSN: 2661-8850