From: Optical biosensor differentiates signaling of endogenous PAR1 and PAR2 in A431 cells
Ligand | EC50(n = 3) | ||
---|---|---|---|
 | Ca2+flux assay | P-DMR | N-DMR |
Trypsin | 45.7 ± 5.8 nM | 98.0 ± 27.8 nM | 102.1 ± 21.9 nM |
SLIGRL-amide | 2.5 ± 0.3 μM | 2.3 ± 0.6 μM | 3.2 ± 0.8 μM |
SLIGKV-amide | 3.8 ± 0.4 μM | 6.1 ± 1.0 μM | 9.1 ± 2.2 μM |
Thrombin | 6.0 ± 1.0 unit/ml | 9.6 ± 2.0 unit/ml | 11.0 ± 1.9 unit/ml |
SFLLR-amide | 5.0 ± 0.4 μM | 1.9 ± 0.1 μM | 3.1 ± 0.2 μM |