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Figure 5 | BMC Cell Biology

Figure 5

From: A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung

Figure 5

Effect of JNK inhibition on NB TGF-β1-induced alterations in lung architecture. NB TGF-β1 TG and WT liter-mate control mice on dox or regular water, with or without treatment with JNKi, were sacrificed at PN10, with activation of TGF-β1 at PN7. H&E staining of lung histology in low (10X; top row) and high (from inset in upper panel; 20X; bottom row) power magnification is shown demonstrating partial rescue of altered alveolar architecture of NB TGF-β1 TG mice lungs with JNKi (5A and 5B). The figures are illustrative of a minimum of 4 animals in each group. Alveolar size, as measured by chord length, confirmed the above observations (5C). Each bar represents the mean ± SEM of a minimum of three animals. NB: newborn; WT: wild type; TGF-β1: transforming growth factor beta1 transgenic; Reg: regular water; Dox: doxcycline water; JNKi: JNK inhibitor. #P ≤ 0.01, ##P ≤ 0.001.

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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