Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport

Table 1 Effect of protein degradation inhibitors on intracellular PC levels.

Transient transfected CHO-K1 cells expressing WT or A267T PC were incubated with medium containing 10 μM lactacystin or 100 nM bafilomycin for 24 and 8 h, respectively. PC protein levels were measured in cell lysates and results are calculated as percentage of controls (samples not treated with protein degradation inhibitors). Data are presented as mean ± SEM. *p < 0.05 (Wilcoxon test).

ISSN: 2661-8850