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Figure 1 | BMC Cell Biology

Figure 1

From: Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility

Figure 1

Tumor promoters increase paracellular permeability of human pancreatic epithelial cell monolayers. Confluent HPAF-II cell monolayers were exposed to either vehicle, or two concentrations of OI-V or TPA, and the integrity of the paracellular barrier was evaluated by transepithelial electrical resistance (TEER) measurements. Both tumor promoters induce a rapid and dose-dependent decrease in TEER, thus indicating the increase in paracellular permeability.

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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