Table 1 A summary of the anti-angiogenic properties of stilbene glycosides.
From: Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis
Assay | Compound 1 | Compound 2 | ||
|---|---|---|---|---|
BAEC | HDMEC | BAEC | HDMEC | |
Proliferation in 15% FBS | NS | NS | NS | NS |
EGF-induced proliferation | NS | NS | NS | NS |
VEGF-induced proliferation | NS | NS | NS | NS |
FGF-2-induced proliferation | 48.90 ± 0.40 | 42.0 ± 0.93 | NS | 101.0 ± 0.50 |
FGF-2-induced migration | 41.8 ± 0.95 | ND | NS | ND |
FGF-2-induced chemotaxis | 30.05 ± 0.85 | 21.50 ± 0.6 | 800.0 ± 2.78 | 953.1 ± 3.50 |
FGF-2-induced tube formation | 18.20 ± 0.65 | 12.4 ± 0.85 | NS | NS |
FGF-2 invasion in matrigel | 11.12 ± 0.28 | 5.8 ± 0.18 | 18.90 ± 0.50 | 32.46 ± 0.95 |
Tubular regression | 40.0 ± 0.2 | ND | 37.42 ± 0.63 | ND |
Effect on binding to FGFR-1 | 5.37 ± 1.04 | NS | ||
Effect on binding to FGFR-2 | 9.32 ± 0.082 | NS | ||
In vivo CAM assay | 100% inhibition | 90% inhibition | ||