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  1. Content type: Research article

    Dental pulp stem cells (DPSCs) are increasingly being recognized as a viable cell source for regenerative medicine. Although significant variations in their ex vivo expansion are well-established, DPSC prolife...

    Authors: Amr Alraies, Nadia Y. A. Alaidaroos, Rachel J. Waddington, Ryan Moseley and Alastair J. Sloan

    Citation: BMC Cell Biology 2017 18:12

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  2. Content type: Research article

    To cause an economically important blast disease on rice, the filamentous fungus Magnaporthe oryzae forms a specialized infection structure, called an appressorium, to penetrate host cells. Once inside host cells...

    Authors: Emma N. Shipman, Kiersun Jones, Cory B. Jenkinson, Dong Won Kim, Jie Zhu and Chang Hyun Khang

    Citation: BMC Cell Biology 2017 18:11

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  3. Content type: Research article

    Sprouting angiogenesis requires vascular endothelial proliferation, migration and morphogenesis. The process is regulated by soluble factors, principally vascular endothelial growth factor (VEGF), and via bidi...

    Authors: M. Jarad, E. A. Kuczynski, J. Morrison, A. M. Viloria-Petit and B. L. Coomber

    Citation: BMC Cell Biology 2017 18:10

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  4. Content type: Review

    Gap junctions are unique membrane channels that play a significant role in intercellular communication in the developing and mature central nervous system (CNS). These channels are composed of connexin protein...

    Authors: Andrei B. Belousov, Joseph D. Fontes, Moises Freitas-Andrade and Christian C. Naus

    Citation: BMC Cell Biology 2017 18(Suppl 1):4

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    This article is part of a Supplement: Volume 18 Supplement 1

  5. Content type: Review

    Gap junction channels (GJCs) are massive protein channels connecting the cytoplasm of adjacent cells. These channels allow intercellular transfer of molecules up to ~1 kDa, including water, ions and other meta...

    Authors: F. Villanelo, Y. Escalona, C. Pareja-Barrueto, J. A. Garate, I. M. Skerrett and T. Perez-Acle

    Citation: BMC Cell Biology 2017 18(Suppl 1):5

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    This article is part of a Supplement: Volume 18 Supplement 1

  6. Content type: Review

    Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins or panne...

    Authors: Daniela Begandt, Miranda E Good, Alex S. Keller, Leon J. DeLalio, Carol Rowley, Brant E. Isakson and Xavier F. Figueroa

    Citation: BMC Cell Biology 2017 18(Suppl 1):2

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    This article is part of a Supplement: Volume 18 Supplement 1

  7. Content type: Review

    The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epit...

    Authors: Viviana M. Berthoud and Anaclet Ngezahayo

    Citation: BMC Cell Biology 2017 18(Suppl 1):6

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    This article is part of a Supplement: Volume 18 Supplement 1

  8. Content type: Review

    This review comes after the International Gap Junction Conference (IGJC 2015) and describes the current knowledge on the function of the specific motifs of connexins in the regulation of the formation of gap j...

    Authors: Thomas Desplantez

    Citation: BMC Cell Biology 2017 18(Suppl 1):3

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    This article is part of a Supplement: Volume 18 Supplement 1

  9. Content type: Research article

    MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regul...

    Authors: Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang and Lin Liu

    Citation: BMC Cell Biology 2017 18:9

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  10. Content type: Research

    Obstructive sleep apnea has been linked to the development of heart disease and arrhythmias, including atrial fibrillation. Since altered conduction through gap junction channels can contribute to the pathogen...

    Authors: Joanna Gemel, Zihan Su, Alex Gileles-Hillel, Abdelnaby Khalyfa, David Gozal and Eric C. Beyer

    Citation: BMC Cell Biology 2017 18(Suppl 1):7

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    This article is part of a Supplement: Volume 18 Supplement 1

  11. Content type: Research article

    Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural...

    Authors: Elizabeth R. Smith, Yue Meng, Robert Moore, Jeffrey D. Tse, Arn G. Xu and Xiang-Xi Xu

    Citation: BMC Cell Biology 2017 18:8

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  12. Content type: Methodology article

    Imaging large volumes such as entire cells or small model organisms at nanoscale resolution seemed an unrealistic, rather tedious task so far. Now, technical advances have lead to several electron microscopy (...

    Authors: Irene Wacker, Waldemar Spomer, Andreas Hofmann, Marlene Thaler, Stefan Hillmer, Ulrich Gengenbach and Rasmus R. Schröder

    Citation: BMC Cell Biology 2016 17:38

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  13. Content type: Research article

    The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is exte...

    Authors: Callinice D. Capo-chichi, Toni M. Yeasky, Elizabeth R. Smith and Xiang-Xi Xu

    Citation: BMC Cell Biology 2016 17:37

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    The Erratum to this article has been published in BMC Cell Biology 2017 18:1

  14. Content type: Research article

    To explore the relationship between spatial genome organization and gene expression in the interphase nucleus, we used a genomic imprinting model, which offers parental-specific gene expression. Using 3D FISH ...

    Authors: Yvette Lahbib-Mansais, Harmonie Barasc, Maria Marti-Marimon, Florence Mompart, Eddie Iannuccelli, David Robelin, Juliette Riquet and Martine Yerle-Bouissou

    Citation: BMC Cell Biology 2016 17:35

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  15. Content type: Research article

    Mitochondrial dysfunction is one of the leading causes of neurological disorders in humans. Mitochondrial perturbations lead to adaptive mechanisms that include HIF-1 stabilization, though the consequences of ...

    Authors: Muntasir Kamal, Dayana R. D’Amora and Terrance J. Kubiseski

    Citation: BMC Cell Biology 2016 17:34

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  16. Content type: Research

    Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. ...

    Authors: David Dickerson, Marek Gierliński, Vijender Singh, Etsushi Kitamura, Graeme Ball, Tomoyuki U. Tanaka and Tom Owen-Hughes

    Citation: BMC Cell Biology 2016 17:33

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  17. Content type: Research article

    Formins are a highly conserved family of cytoskeletal remodeling proteins. A growing body of evidence suggests that formins play key roles in the progression and spread of a variety of cancers. There are 15 hu...

    Authors: Christine Péladeau, Allan Heibein, Melissa T. Maltez, Sarah J. Copeland and John W. Copeland

    Citation: BMC Cell Biology 2016 17:32

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  18. Content type: Research article

    The serine/threonine kinase PAK1 is an important regulator of cell motility. Both PAK1 and the hormone/cytokine prolactin (PRL) have been implicated in breast cancer cell motility, however, the exact mechanism...

    Authors: Alan Hammer and Maria Diakonova

    Citation: BMC Cell Biology 2016 17:31

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  19. Content type: Methodology article

    Karyotypic integrity is essential for the successful germline transmission of alleles mutated in embryonic stem (ES) cells. Classical methods for the identification of aneuploidy involve cytological analyses t...

    Authors: Gemma F. Codner, Loic Lindner, Adam Caulder, Marie Wattenhofer-Donzé, Adam Radage, Annelyse Mertz, Benjamin Eisenmann, Joffrey Mianné, Edward P. Evans, Colin V. Beechey, Martin D. Fray, Marie-Christine Birling, Yann Hérault, Guillaume Pavlovic and Lydia Teboul

    Citation: BMC Cell Biology 2016 17:30

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  20. Content type: Research article

    Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accompl...

    Authors: Clemens Cammann, Alexander Rath, Udo Reichl, Holger Lingel, Monika Brunner-Weinzierl, Luca Simeoni, Burkhart Schraven and Jonathan A. Lindquist

    Citation: BMC Cell Biology 2016 17:28

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  21. Content type: Research article

    Vacuolar-type proton pumps help maintain acid–base homeostasis either within intracellular compartments or at specialised plasma membranes. In mammals they are made up of 13 subunits, which form two functional...

    Authors: Zoe J. Golder and Fiona E. Karet Frankl

    Citation: BMC Cell Biology 2016 17:27

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  22. Content type: Research article

    Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is prese...

    Authors: Ian Holt, Nguyen Thuy Duong, Qiuping Zhang, Le Thanh Lam, Caroline A. Sewry, Kamel Mamchaoui, Catherine M. Shanahan and Glenn E. Morris

    Citation: BMC Cell Biology 2016 17:26

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  23. Content type: Research article

    Vascular endothelial dysfunction is the closely related determinant of ischemic heart disease (IHD). Endothelial dysfunction and ischemia/reperfusion injury (IRI) have been associated with an increase in micro...

    Authors: Qi Zhang, Man Shang, Mengxiao Zhang, Yao Wang, Yan Chen, Yanna Wu, Minglin Liu, Junqiu Song and Yanxia Liu

    Citation: BMC Cell Biology 2016 17:25

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  24. Content type: Research article

    Flagella and cilia are fine thread-like organelles protruding from cells that harbour them. The typical ‘9 + 2’ cilia confer motility on these cells. Although the mechanistic details of motility remain elusive...

    Authors: Venkatramanan G. Rao, Ruhi B. Sarafdar, Twinkle S. Chowdhury, Priyanka Sivadas, Pinfen Yang, Prabhakar M. Dongre and Jacinta S. D’Souza

    Citation: BMC Cell Biology 2016 17:24

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  25. Content type: Research article

    Ankyrin repeats and LEM domain containing protein 1 (Ankle1) belongs to the LEM protein family, whose members share a chromatin-interacting LEM motif. Unlike most other LEM proteins, Ankle1 is not an integral ...

    Authors: Livija Zlopasa, Andreas Brachner and Roland Foisner

    Citation: BMC Cell Biology 2016 17:23

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  26. Content type: Review

    Post-translational modifications of connexins play an important role in the regulation of gap junction and hemichannel permeability. The prerequisite for the formation of functional gap junction channels is th...

    Authors: Kristin Pogoda, Petra Kameritsch, Mauricio A. Retamal and José L. Vega

    Citation: BMC Cell Biology 2016 17(Suppl 1):11

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    This article is part of a Supplement: Volume 17 Supplement 1

  27. Content type: Review

    Electrical synapses are an omnipresent feature of nervous systems, from the simple nerve nets of cnidarians to complex brains of mammals. Formed by gap junction channels between neurons, electrical synapses al...

    Authors: Sebastian Curti and John O’Brien

    Citation: BMC Cell Biology 2016 17(Suppl 1):13

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    This article is part of a Supplement: Volume 17 Supplement 1

  28. Content type: Review

    Gap junctions mediate electrical synaptic transmission between neurons. While the actions of neurotransmitter modulators on the conductance of gap junctions have been extensively documented, increasing evidenc...

    Authors: Julie S. Haas, Corey M. Greenwald and Alberto E. Pereda

    Citation: BMC Cell Biology 2016 17(Suppl 1):14

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    This article is part of a Supplement: Volume 17 Supplement 1

  29. Content type: Research

    Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, in...

    Authors: Luis A. Cea, Jorge A. Bevilacqua, Christian Arriagada, Ana María Cárdenas, Anne Bigot, Vincent Mouly, Juan C. Sáez and Pablo Caviedes

    Citation: BMC Cell Biology 2016 17(Suppl 1):15

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    This article is part of a Supplement: Volume 17 Supplement 1

  30. Content type: Review

    Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function ...

    Authors: Jean X. Jiang and Silvia Penuela

    Citation: BMC Cell Biology 2016 17(Suppl 1):S12

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    This article is part of a Supplement: Volume 17 Supplement 1

  31. Content type: Review

    Internalization of gap junction plaques results in the formation of annular gap junction vesicles. The factors that regulate the coordinated internalization of the gap junction plaques to form annular gap junc...

    Authors: Matthias M. Falk, Cheryl L. Bell, Rachael M. Kells Andrews and Sandra A. Murray

    Citation: BMC Cell Biology 2016 17(Suppl 1):S22

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    This article is part of a Supplement: Volume 17 Supplement 1

  32. Content type: Review

    Connexins and pannexins share very similar structures and functions; they also exhibit overlapping expression in many stages of neuronal development. Here, we review evidence implicating connexin- and pannexin...

    Authors: Leigh Anne Swayne and Steffany A. L. Bennett

    Citation: BMC Cell Biology 2016 17(Suppl 1):S10

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    This article is part of a Supplement: Volume 17 Supplement 1

  33. Content type: Review

    Mutations in human connexin (Cx) genes have been related to diseases, which we termed connexinopathies. Such hereditary disorders include nonsyndromic or syndromic deafness (Cx26, Cx30), Charcot Marie Tooth di...

    Authors: Isaac E. García, Pavel Prado, Amaury Pupo, Oscar Jara, Diana Rojas-Gómez, Paula Mujica, Carolina Flores-Muñoz, Jorge González-Casanova, Carolina Soto-Riveros, Bernardo I. Pinto, Mauricio A. Retamal, Carlos González and Agustín D. Martínez

    Citation: BMC Cell Biology 2016 17(Suppl 1):S17

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    This article is part of a Supplement: Volume 17 Supplement 1

  34. Content type: Review

    Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a ...

    Authors: Jegan Iyyathurai, Jean-Paul Decuypere, Luc Leybaert, Catheleyne D’hondt and Geert Bultynck

    Citation: BMC Cell Biology 2016 17(Suppl 1):S20

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    This article is part of a Supplement: Volume 17 Supplement 1

  35. Content type: Review

    Electron micrographs revealed the presence of gap junctions in osteoblastic cells over 40 years ago. These intercellular channels formed from connexins are present in bone forming osteoblasts, bone resorbing o...

    Authors: Lilian I. Plotkin, Dale W. Laird and Joelle Amedee

    Citation: BMC Cell Biology 2016 17(Suppl 1):S19

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    This article is part of a Supplement: Volume 17 Supplement 1

  36. Content type: Research article

    Endothelial-mesenchymal transition (EndoMT) is a major source of myofibroblast formation in kidney fibrosis. Our previous study showed a profibrotic role for matrix metalloproteinase 9 (MMP-9) in kidney fibros...

    Authors: Ye Zhao, Xi Qiao, Lihua Wang, Tian Kui Tan, Hong Zhao, Yun Zhang, Jianlin Zhang, Padmashree Rao, Qi Cao, Yiping Wang, Ya Wang, Yuan Min Wang, Vincent W. S. Lee, Stephen I. Alexander, David C. H. Harris and Guoping Zheng

    Citation: BMC Cell Biology 2016 17:21

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  37. Content type: Research article

    IL-27 is a multifunctional cytokine that has both pro-inflammatory and anti-inflammatory functions. Although IL-27 has been shown to potently inhibit lung fibrosis, the detailed mechanism of IL-27 in this proc...

    Authors: Zhaoxing Dong, Wenlin Tai, Wen Lei, Yin Wang, ZhenKun Li and Tao Zhang

    Citation: BMC Cell Biology 2016 17:7

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  38. Content type: Reviewer acknowledgement

    The editors of BMC Cell Biology would like to thank all those who have contributed reviews to the journal in Volume 16 (2015).

    Authors: Timothy R. Sands

    Citation: BMC Cell Biology 2016 17:6

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  39. Content type: Research article

    Gap junctions facilitate exchange of small molecules between adjacent cells, serving a crucial function for the maintenance of cellular homeostasis. Mutations in connexins, the basic unit of gap junctions, are...

    Authors: Hande Aypek, Veysel Bay and Gülistan Meşe

    Citation: BMC Cell Biology 2016 17:5

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  40. Content type: Research article

    The intestinal cells of Caenorhabditis elegans are filled with heterogeneous granular organelles that are associated with specific organ functions. The best studied of these organelles are lipid droplets and acid...

    Authors: Takahiro Tanji, Kenji Nishikori, Syoko Haga, Yuki Kanno, Yusuke Kobayashi, Mai Takaya, Keiko Gengyo-Ando, Shohei Mitani, Hirohisa Shiraishi and Ayako Ohashi-Kobayashi

    Citation: BMC Cell Biology 2016 17:4

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  41. Content type: Research article

    Membranous tunneling tubes (TTs) are a recently discovered new form of communication between remote cells allowing their electrical synchronization, migration, and transfer of cellular materials. TTs have been...

    Authors: Lina Rimkutė, Vaidas Jotautis, Alina Marandykina, Renata Sveikatienė, Ieva Antanavičiūtė and Vytenis Arvydas Skeberdis

    Citation: BMC Cell Biology 2016 17:3

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  42. Content type: Research article

    The small G-protein Rap1 is an important regulator of cellular adhesion in Dictyostelium, however so far the downstream signalling pathways for cell adhesion are not completely characterized. In mammalian cells t...

    Authors: Katarzyna Plak, Henderikus Pots, Peter J. M. Van Haastert and Arjan Kortholt

    Citation: BMC Cell Biology 2016 17:1

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