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  1. Research article

    Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression

    Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural...

    Elizabeth R. Smith, Yue Meng, Robert Moore, Jeffrey D. Tse, Arn G. Xu and Xiang-Xi Xu

    BMC Cell Biology 2017 18:8

    Published on: 14 January 2017

  2. Methodology article

    Hierarchical imaging: a new concept for targeted imaging of large volumes from cells to tissues

    Imaging large volumes such as entire cells or small model organisms at nanoscale resolution seemed an unrealistic, rather tedious task so far. Now, technical advances have lead to several electron microscopy (...

    Irene Wacker, Waldemar Spomer, Andreas Hofmann, Marlene Thaler, Stefan Hillmer, Ulrich Gengenbach and Rasmus R. Schröder

    BMC Cell Biology 2016 17:38

    Published on: 12 December 2016

  3. Research article

    Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis

    The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is exte...

    Callinice D. Capo-chichi, Toni M. Yeasky, Elizabeth R. Smith and Xiang-Xi Xu

    BMC Cell Biology 2016 17:37

    Published on: 22 November 2016

    The Erratum to this article has been published in BMC Cell Biology 2017 18:1

  4. Research article

    Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells

    To explore the relationship between spatial genome organization and gene expression in the interphase nucleus, we used a genomic imprinting model, which offers parental-specific gene expression. Using 3D FISH ...

    Yvette Lahbib-Mansais, Harmonie Barasc, Maria Marti-Marimon, Florence Mompart, Eddie Iannuccelli, David Robelin, Juliette Riquet and Martine Yerle-Bouissou

    BMC Cell Biology 2016 17:35

    Published on: 1 October 2016

  5. Research

    High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division

    Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. ...

    David Dickerson, Marek Gierliński, Vijender Singh, Etsushi Kitamura, Graeme Ball, Tomoyuki U. Tanaka and Tom Owen-Hughes

    BMC Cell Biology 2016 17:33

    Published on: 8 September 2016

  6. Research article

    A specific FMNL2 isoform is up-regulated in invasive cells

    Formins are a highly conserved family of cytoskeletal remodeling proteins. A growing body of evidence suggests that formins play key roles in the progression and spread of a variety of cancers. There are 15 hu...

    Christine Péladeau, Allan Heibein, Melissa T. Maltez, Sarah J. Copeland and John W. Copeland

    BMC Cell Biology 2016 17:32

    Published on: 30 August 2016

  7. Methodology article

    Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction

    Karyotypic integrity is essential for the successful germline transmission of alleles mutated in embryonic stem (ES) cells. Classical methods for the identification of aneuploidy involve cytological analyses t...

    Gemma F. Codner, Loic Lindner, Adam Caulder, Marie Wattenhofer-Donzé, Adam Radage, Annelyse Mertz, Benjamin Eisenmann, Joffrey Mianné, Edward P. Evans, Colin V. Beechey, Martin D. Fray, Marie-Christine Birling, Yann Hérault, Guillaume Pavlovic and Lydia Teboul

    BMC Cell Biology 2016 17:30

    Published on: 5 August 2016

  8. Research article

    Early changes in the metabolic profile of activated CD8+ T cells

    Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accompl...

    Clemens Cammann, Alexander Rath, Udo Reichl, Holger Lingel, Monika Brunner-Weinzierl, Luca Simeoni, Burkhart Schraven and Jonathan A. Lindquist

    BMC Cell Biology 2016 17:28

    Published on: 7 July 2016

  9. Research article

    Extra-renal locations of the a4 subunit of H+ATPase

    Vacuolar-type proton pumps help maintain acid–base homeostasis either within intracellular compartments or at specialised plasma membranes. In mammals they are made up of 13 subunits, which form two functional...

    Zoe J. Golder and Fiona E. Karet Frankl

    BMC Cell Biology 2016 17:27

    Published on: 2 July 2016

  10. Research article

    Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody

    Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is prese...

    Ian Holt, Nguyen Thuy Duong, Qiuping Zhang, Le Thanh Lam, Caroline A. Sewry, Kamel Mamchaoui, Catherine M. Shanahan and Glenn E. Morris

    BMC Cell Biology 2016 17:26

    Published on: 27 June 2016

  11. Research article

    Microvesicles derived from hypoxia/reoxygenation-treated human umbilical vein endothelial cells promote apoptosis and oxidative stress in H9c2 cardiomyocytes

    Vascular endothelial dysfunction is the closely related determinant of ischemic heart disease (IHD). Endothelial dysfunction and ischemia/reperfusion injury (IRI) have been associated with an increase in micro...

    Qi Zhang, Man Shang, Mengxiao Zhang, Yao Wang, Yan Chen, Yanna Wu, Minglin Liu, Junqiu Song and Yanxia Liu

    BMC Cell Biology 2016 17:25

    Published on: 23 June 2016

  12. Research article

    Myc-binding protein orthologue interacts with AKAP240 in the central pair apparatus of the Chlamydomonas flagella

    Flagella and cilia are fine thread-like organelles protruding from cells that harbour them. The typical ‘9 + 2’ cilia confer motility on these cells. Although the mechanistic details of motility remain elusive...

    Venkatramanan G. Rao, Ruhi B. Sarafdar, Twinkle S. Chowdhury, Priyanka Sivadas, Pinfen Yang, Prabhakar M. Dongre and Jacinta S. D’Souza

    BMC Cell Biology 2016 17:24

    Published on: 10 June 2016

  13. Research article

    Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals

    Ankyrin repeats and LEM domain containing protein 1 (Ankle1) belongs to the LEM protein family, whose members share a chromatin-interacting LEM motif. Unlike most other LEM proteins, Ankle1 is not an integral ...

    Livija Zlopasa, Andreas Brachner and Roland Foisner

    BMC Cell Biology 2016 17:23

    Published on: 1 June 2016

  14. Review

    Connexin and pannexin channels in cancer

    Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function ...

    Jean X. Jiang and Silvia Penuela

    BMC Cell Biology 2016 17(Suppl 1):S12

    Published on: 24 May 2016

    This article is part of a Supplement: Volume 17 Supplement 1

  15. Review

    Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions

    Internalization of gap junction plaques results in the formation of annular gap junction vesicles. The factors that regulate the coordinated internalization of the gap junction plaques to form annular gap junc...

    Matthias M. Falk, Cheryl L. Bell, Rachael M. Kells Andrews and Sandra A. Murray

    BMC Cell Biology 2016 17(Suppl 1):S22

    Published on: 24 May 2016

    This article is part of a Supplement: Volume 17 Supplement 1

  16. Review

    Connexinopathies: a structural and functional glimpse

    Mutations in human connexin (Cx) genes have been related to diseases, which we termed connexinopathies. Such hereditary disorders include nonsyndromic or syndromic deafness (Cx26, Cx30), Charcot Marie Tooth di...

    Isaac E. García, Pavel Prado, Amaury Pupo, Oscar Jara, Diana Rojas-Gómez, Paula Mujica, Carolina Flores-Muñoz, Jorge González-Casanova, Carolina Soto-Riveros, Bernardo I. Pinto, Mauricio A. Retamal, Carlos González and Agustín D. Martínez

    BMC Cell Biology 2016 17(Suppl 1):S17

    Published on: 24 May 2016

    This article is part of a Supplement: Volume 17 Supplement 1

  17. Review

    Connexins: substrates and regulators of autophagy

    Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a ...

    Jegan Iyyathurai, Jean-Paul Decuypere, Luc Leybaert, Catheleyne D’hondt and Geert Bultynck

    BMC Cell Biology 2016 17(Suppl 1):S20

    Published on: 24 May 2016

    This article is part of a Supplement: Volume 17 Supplement 1

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