Connexin26 mutations and KID syndrome
This micrograph shows a cell with a D50Y mutation in connexin26. Cx26 protein (red) and golgin-97 (green) colocalize more frequently than in wildtype cells. D50Y and I30N mutations result in the formation of aberrant hemichannels that might elevate intracellular calcium levels, which may contribute to the hyperproliferative epidermal phenotypes of KID syndrome.
Aypek et al. BMC Cell Biol. 17:5
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BMC Molecular and Cell Biology, formerly known as BMC Cell Biology, is an open access journal that considers articles on all aspects of both eukaryotic and prokaryotic cell and molecular biology, including structural and functional cell biology, DNA and RNA in a cellular context and biochemistry, as well as research using both the experimental and theoretical aspects of physics to study biological processes and investigations into the structure of biological macromolecules.
Alison Cuff, BioMed Central
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