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Fig. 10 | BMC Molecular and Cell Biology

Fig. 10

From: Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues

Fig. 10

Summary of the circadian disruptions (highlighted in red arrows and boxes) caused by DIO3 deficiency. Dio3-/- flattened or completely erased the circadian rhythm of gene expression in different tissues by T3 effects through the hypothalamic-pituitary-adrenal (HPA) axis without disrupting the circadian rhythm of clock genes in the specific mouse tissue

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