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Fig. 7 | BMC Molecular and Cell Biology

Fig. 7

From: Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells

Fig. 7

Proposed mechanism of cyclic mechanical stretch-induced caveolin-1 trafficking in vascular smooth muscle cells. Mechanical stimulation promotes caveolae endocytosis in a dynamin-dependent process, reducing caveolin-1 levels in the plasma membrane. Caveolin-1 is subsequently trafficked to the cytosol and incorporated into extracellular vesicles, leading to increased release. The extracellular vesicles from stretched cells exhibit increased alkaline phosphatase (ALP) activity. RhoA kinase (ROCK) mediates actin cytoskeleton remodeling in response to stretch, which regulates caveolin-1 mobilization

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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