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Fig. 6 | BMC Molecular and Cell Biology

Fig. 6

From: Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells

Fig. 6

Osteogenic factors and cyclic stretch induce pro-calcific VSMC phenotype and EV release. A Osteogenic media increased EV Cav-1 1.85-fold and stretch augmented Cav-1 2.5-fold. B Osteogenic conditions elevated EV annexin V 0.88-fold and 0.86-fold with stretch and non-stretch. C EV alkaline phosphatase (ALP) rose 5.86-fold and 3.44-fold in osteogenic media with stretch and non-stretch. Stretch also increased EV ALP 0.7-fold in normal media. D Cellular ALP increased 12.5-fold and 12.2-fold with osteogenic media and stretch reduced intracellular ALP 0.35-fold and 0.36-fold. n = 6. Data are mean ± SD (**P < 0.01, ***P < 0.001, ****P < 0.0001). Full-length blots are presented in Supplementary Fig. 6

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BMC Molecular and Cell Biology

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