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Table 3 Prioritized hub editosome PPIs properties

From: Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis

Hub PPI

Interface length*

Average PAE

Average RIN MCDA

Rank †

Top 3 interface hotspots

KREL1-KREPA2

7

4.12

0.70

3

N429, E433, L425

RESC3-RESC2

8

7.40

0.53

6

Y446, H407, L475

RESC10-RESC6

13

2.91

0.58

4

K303, V100, P99

KREL2-KREPA1

8

1.26

0.69

1

F393, Y390, R396

RESC2-RESC1

15

2.06

0.60

2

H345, Y250, R220

RESC12A-RESC13

8

2.56

0.54

4

E644, Y598, R641

  1. * Each residue from the hub protein within the interface may interact with more than one residue from the target protein
  2. † Using dual-criteria ranking approach based on the average PAE and average RIN MCDA
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BMC Molecular and Cell Biology

ISSN: 2661-8850

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