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Table 1 List of top ten hub proteins of editosome PPI network in T. brucei and their centrality measures

From: Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis

Rank

TriTryp ID

Name

Betweenness*

Closeness*

Degree*

MCDA score

1

Tb927.1.3030

KREL2

1532.5881

0.1580

11

0.8261

2

Tb927.11.16860

RESC3

422.2286

0.1915

16.5

0.7530

3

Tb927.6.1680

KH2F1

1334.1823

0.1712

8

0.7449

4

Tb927.7.800

RESC10

464.2319

0.1903

14.125

0.7122

5

Tb927.9.4360

KREL1

733.3652

0.1733

11.375

0.6860

6

Tb927.5.3010

RESC6

243.2760

0.1891

15.25

0.6847

7

Tb927.10.10830

RESC13

275.5744

0.1881

14.875

0.6825

8

Tb927.2.3800

RESC2

347.8233

0.1947

13.375

0.6792

9

Tb927.8.8170

RESC12a

302.1332

0.1809

14.125

0.6608

10

Tb927.4.1500

KREH2

140.5734

0.1899

13

0.6183

  1. * Degree: Number of direct interactions a protein has; Closeness: Measures how quickly a protein can interact with all others; Betweenness: Identifies proteins critical for connecting others in the network
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BMC Molecular and Cell Biology

ISSN: 2661-8850

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