Fig. 3
From: Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Dec1 KO mice had inhibited fatty acid degeneration induced by 10% alcohol. (A) Macroscopic features of two independent WT (WT1 and WT2) and Dec1 KO (Dec1 KO1 and Dec1 KO2) livers after 10% alcohol consumption. WT mice show severe hepatic congestion, but Dec1 KO mice show little change. (B) Microscopy revealed severe lipid degeneration and congestion in the livers of WT mice, whereas Dec1 KO mice were minimally affected. Top panel, 200 x magnification. Bottom panel, 400 x magnification. Arrows show lipid degeneration. Dotted arrows show central vein. Scale bars, 100 µM. (C) Average numbers of lipid degeneration locations in three independent samples. Lipid degeneration around the central vein was counted in ten microscopic fields under 400 x magnification. *P < 0.01, based on the t-test. The raw data are shown in the Supplementary File