Table 4 Categories of top enriched pathways identified by Gene Set Enrichment Analysis (GSEA) of proteomic dataset

Functions related to syndecan-1

SIZE

p-val

rank

 REACTOME_COLLAGEN_FORMATION

28

≤0.001

1

 REACTOME_NCAM1_INTERACTIONS

16

≤0.001

2

 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

38

≤0.001

3

 KEGG_ECM_RECEPTOR_INTERACTION

51

≤0.001

4

 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

16

0.002

10

 REACTOME_CHONDROITIN_SULFATE_DERMATAN_ SULFATE_METABOLISM

29

0.001

16

 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

47

≤0.001

17

 KEGG_CELL_ADHESION_MOLECULES_CAMS

47

≤0.001

 REACTOME_GLYCOSAMINOGLYCAN_METABOLISM

57

0.001

28

 KEGG_FOCAL_ADHESION

137

≤0.001

34

 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES

154

0.001

41

 REACTOME_CELL_JUNCTION_ORGANIZATION

36

0.032

42

 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM

27

0.045

56

TGF β

SIZE

p-val

rank

 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

17

0.014

26

 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

19

0.018

27

 KEGG_TGF_BETA_SIGNALING_PATHWAY

44

0.019

45

Immune System

SIZE

p-val

rank

 KEGG_HEMATOPOIETIC_CELL_LINEAGE

25

0.001

12

 REACTOME_INTERFERON_GAMMA_SIGNALING

32

0.001

15

 REACTOME_IMMUNOREG_INTERACTIONS_BETWEEN_A_LYMPHOID_ AND_A_NON_LYMPHOID_CELL

16

0.005

18

 BIOCARTA_IL1R_PATHWAY

24

0.001

23

 REACTOME_IL1_SIGNALING

27

0.014

33

 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

58

0.023

63