Fig. 1

Nuclear translocation of syndecan-1 inhibits fibrosarcoma cell proliferation. a B6FS fibrosarcoma cells transfected with full-length (FLs1), syndecan-1 lacking the nuclear localization signal (NLSdel) and corresponding empty vector (empty) were seeded at a density of 3000 cells/well in 96 well plates and absorbance values were measured using WST-1 proliferation assay. Symbols represent the mean ± SD (n = 3). Cell proliferation increased when the nuclear translocation of syndecan-1 was impaired in the NLS deleted construct (p = 0.018). b Doubling time of cells transfected with different constructs shows that NLSdel grows faster while the difference between FLs1 and control is not significant. Bars represent the average of three independent experiments ±SD. *p < 0.05, based on the paired t-test