Figure 7From: PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in miceThe Atf4 KO mice show pancreatic hypotrophy. As early as P4, Atf4 KO mice show fewer and smaller acinar cells in the exocrine pancreas (A, P4 wild-type; B, P4 Atf4 KO, 400x). The arrows point to tubular structures. By three months of age, the majority of the exocrine pancreas is replaced by adipocytes (C, Atf4 KO).Back to article page