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  1. Content type: Research article

    The transcription factor E2F4 controls proliferation of normal and cancerous intestinal epithelial cells. E2F4 localization in normal human intestinal epithelial cells (HIEC) is cell cycle-dependent, being cyt...

    Authors: Marie-Christine Paquin, Sébastien Cagnol, Julie C Carrier, Caroline Leblanc and Nathalie Rivard

    Citation: BMC Cell Biology 2013 14:33

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  2. Content type: Research article

    Apoptosis is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade responsible for executing cell death following cytochrome c release is well d...

    Authors: Matthew Brentnall, Luis Rodriguez-Menocal, Rebeka Ladron De Guevara, Enrique Cepero and Lawrence H Boise

    Citation: BMC Cell Biology 2013 14:32

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  3. Content type: Research article

    In the progression towards diabetes, glucolipotoxicity is one of the main causes of pancreatic beta cell pathology. The aim of this study was to examine the in vitro effects of chronic glucolipotoxic conditions o...

    Authors: Baggavalli P Somesh, Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Anup Mammen-Oommen, Sanghamitra Biswas, Pavagada C Shilpa, Ashok Kumar Reddy, Aggunda N Yateesh, Puttrevana M Pallavi, Siddaraju Nethra, Rachapalli Smitha, Korrapati Neelima, Usha Narayanan and Madanahalli R Jagannath

    Citation: BMC Cell Biology 2013 14:31

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  4. Content type: Research article

    While the essential role of 3D nuclear architecture on nuclear functions has been demonstrated for various cell types, information available for neutrophils, essential components of the immune system, remains ...

    Authors: Florence Mompart, David Robelin, Chantal Delcros and Martine Yerle-Bouissou

    Citation: BMC Cell Biology 2013 14:30

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  5. Content type: Research article

    Two pathways are responsible for the majority of regulated protein catabolism in eukaryotic cells: the ubiquitin-proteasome system (UPS) and lysosomal self-degradation through autophagy. Both processes are nec...

    Authors: Péter Lőw, Ágnes Varga, Karolina Pircs, Péter Nagy, Zsuzsanna Szatmári, Miklós Sass and Gábor Juhász

    Citation: BMC Cell Biology 2013 14:29

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  6. Content type: Research article

    Renal podocytes form the main filtration barrier possessing a unique phenotype maintained by proteins including podocalyxin and nephrin, the expression of which is suppressed in pathological conditions. We use...

    Authors: Nikolaos E Tsotakos, Marina Sagnou, Eleni S Kotsopoulou, Effie C Tsilibary and Garyfalia I Drossopoulou

    Citation: BMC Cell Biology 2013 14:28

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  7. Content type: Research article

    Autophagy is a conserved cellular process that degrades and recycles cytoplasmic components via a lysosomal pathway. The phosphatidylethanolamine (PE)-conjugation of the Atg8 protein plays an important role in...

    Authors: Chao Liu, Haijie Ma, Jiaxue Wu, Qiang Huang, Jun O Liu and Long Yu

    Citation: BMC Cell Biology 2013 14:27

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  8. Content type: Research article

    H19 is a paternally imprinted gene that has been shown to be highly expressed in the trophoblast tissue. Results from previous studies have initiated a debate as to whether noncoding RNA H19 acts as a tumor suppr...

    Authors: Li-Li Yu, Kai Chang, Lin-Shan Lu, Dan Zhao, Jian Han, Ying-Ru Zheng, Yao-Hua Yan, Ping Yi, Jian-Xin Guo, Yuan-Guo Zhou, Ming Chen and Li Li

    Citation: BMC Cell Biology 2013 14:26

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  9. Content type: Research article

    The extracellular matrix (ECM) influences the structure, viability and functions of cells and tissues. Recent evidence indicates that tumor cells and stromal cells interact through direct cell-cell contact, th...

    Authors: Carolina Meloni Vicente, Ritchelli Ricci, Helena Bonciani Nader and Leny Toma

    Citation: BMC Cell Biology 2013 14:25

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  10. Content type: Research article

    We have recently characterized two distinct populations of Satellite Cells (SCs) that differ in proliferation, regenerative potential, and mitochondrial coupling efficiency and classified these in Low Prolifer...

    Authors: Andrea Repele, Ramona Lupi, Simon Eaton, Luca Urbani, Paolo De Coppi and Michelangelo Campanella

    Citation: BMC Cell Biology 2013 14:24

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  11. Content type: Research article

    Previous studies have implicated continuous or intermittent hyperglycemia in altered endothelium-derived nitric oxide (NO) synthesis. NO can regulate both the F-actin cytoskeleton and endothelial cell membrane...

    Authors: Xianxian Chen, Lie Feng and Hua Jin

    Citation: BMC Cell Biology 2013 14:22

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  12. Content type: Review

    The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance.

    Authors: Natasha S Barteneva, Elizaveta Fasler-Kan, Michael Bernimoulin, Joel NH Stern, Eugeny D Ponomarev, Larry Duckett and Ivan A Vorobjev

    Citation: BMC Cell Biology 2013 14:23

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  13. Content type: Methodology article

    The scarcity of certain nucleic acid species and the small size of target sequences such as miRNA, impose a significant barrier to subcellular visualization and present a major challenge to cell biologists. He...

    Authors: Kate L Jones, Adam Karpala, Bevan Hirst, Kristie Jenkins, Mark Tizard, Cândida F Pereira, Andrew Leis, Paul Monaghan, Alex Hyatt and Johnson Mak

    Citation: BMC Cell Biology 2013 14:21

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  14. Content type: Research article

    Krabbe disease, also known as globoid cell leukodystrophy, is an autosomal recessive neurodegenerative disease caused by the genetic deficiency of galactocerebrosidase (GALC), a lysosomal enzyme responsible fo...

    Authors: Xiujuan Zhang, Julie A Semon, Shijia Zhang, Amy L Strong, Brittni A Scruggs, Jeffrey M Gimble and Bruce A Bunnell

    Citation: BMC Cell Biology 2013 14:20

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  15. Content type: Research article

    Claudins are key integral proteins of the tight junction. Although they play an essential role in controlling paracellular diffusion in epithelia, increasing evidence supports a role for these proteins in non-...

    Authors: Patricia G Webb, Monique A Spillman and Heidi K Baumgartner

    Citation: BMC Cell Biology 2013 14:19

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  16. Content type: Research article

    Fibroblasts play a critical role in tumorigenesis, tumor progression and metastasis. However, their detailed molecular characteristics and clinical significance are still elusive. TAGLN is an actin-binding pro...

    Authors: Beiqin Yu, Xuehua Chen, Jianfang Li, Ying Qu, Liping Su, Yibing Peng, Jian Huang, Jun Yan, Yingyan Yu, Qinlong Gu, Zhenggang Zhu and Bingya Liu

    Citation: BMC Cell Biology 2013 14:17

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  17. Content type: Research article

    The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats.

    Authors: Jun-qi Guo, Xia Gao, Zhi-jie Lin, Wei-zhen Wu, Liang-hu Huang, Hui-yue Dong, Jin Chen, Jun Lu, Yun-fen Fu, Jin Wang, Yu-jie Ma, Xiao-wen Chen, Zhi-xian Wu, Fu-qiang He, Shun-liang Yang, Lian-ming Liao…

    Citation: BMC Cell Biology 2013 14:18

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  18. Content type: Methodology article

    The kidney-specific NKCC cotransporter isoform NKCC2 is involved in the Na+ reabsorption in the Thich Ascending Limb (TAL) cells and in the regulation of body fluid volume. In contrast, the isoform NKCC1 represen...

    Authors: Monica Carmosino, Federica Rizzo, Silvia Torretta, Giuseppe Procino and Maria Svelto

    Citation: BMC Cell Biology 2013 14:16

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  19. Content type: Research article

    Protein Ser/Thr Phosphatase PPP1CC2 is an alternatively spliced isoform of PPP1C that is highly enriched in testis and selectively expressed in sperm. Addition of the phosphatase inhibitor toxins okadaic acid ...

    Authors: Luis Korrodi-Gregório, Mónica Ferreira, Ana Paula Vintém, Wenjuan Wu, Thorsten Muller, Katrin Marcus, Srinivasan Vijayaraghavan, David L Brautigan, Odete A B da Cruz e Silva, Margarida Fardilha and Edgar F da Cruz e Silva

    Citation: BMC Cell Biology 2013 14:15

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  20. Content type: Research article

    Epidermal growth factor receptor (EGFR) is involved in the development of many human malignant tumors and plays an important role in tumor growth and metastasis. Antagonists of EGFR can suppress the growth of ...

    Authors: Yi Huang, Tao Yu, Xiaoyue Fu, Jiao Chen, Ying Liu, Chunjie Li, Yichao Xia, Zhuoyuan Zhang and Longjiang Li

    Citation: BMC Cell Biology 2013 14:13

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  21. Content type: Research article

    The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and oth...

    Authors: Tomoko Satake, Karin Otsuki, Yumi Banba, Jun Suenaga, Hisashi Hirano, Yuko Yamanaka, Shigeo Ohno and Syu-ichi Hirai

    Citation: BMC Cell Biology 2013 14:12

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  22. Content type: Research article

    In several species with external fertilization, including frogs, laid unfertilized eggs were found to die by apoptosis outside of the animal body. However, there is no apparent reason for the externally laid e...

    Authors: Sho Iguchi, Tetsushi Iwasaki, Yasuo Fukami and Alexander A Tokmakov

    Citation: BMC Cell Biology 2013 14:11

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  23. Content type: Research article

    The transition of epithelial cells from their normal non-motile state to a motile one requires the coordinated action of a number of small GTPases. We have previously shown that epithelial cell migration is st...

    Authors: Myriam A Attar and Lorraine C Santy

    Citation: BMC Cell Biology 2013 14:9

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  24. Content type: Research article

    The goal of this study was to investigate the anti-angiogenic activity of a novel peptide H-RN, derived from the hepatocyte growth factor kringle 1 domain (HGF K1), in a mouse model of corneal neovascularizati...

    Authors: Ye Sun, Li Su, Zhongxiao Wang, Yi Xu and Xun Xu

    Citation: BMC Cell Biology 2013 14:8

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  25. Content type: Research article

    Cancer stem cells (CSCs) are thought to be capable of surviving conventional chemotherapeutic treatments because the cells have more resistant to anticancer drugs than common cancer cells. Most in vitro studies i...

    Authors: Junsong Chen, Jing Wang, Dengyu Chen, Jie Yang, Cuiping Yang, Yunxia Zhang, Hongyi Zhang and Jun Dou

    Citation: BMC Cell Biology 2013 14:7

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  26. Content type: Research article

    Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early development and chemotaxis competent cells RapA induces p...

    Authors: Katarzyna Plak, Douwe Veltman, Fabrizia Fusetti, Jetze Beeksma, Francisco Rivero, Peter JM Van Haastert and Arjan Kortholt

    Citation: BMC Cell Biology 2013 14:6

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  27. Content type: Research article

    The interactions between stem cells and extracellular matrix (ECM) mediated by integrins play important roles in the processes that determine stem cell fate. However, the role of ECM/integrin interaction in th...

    Authors: Di Zeng, Dong-Bo Ou, Ting Wei, Lu Ding, Xiong-Tao Liu, Xin-Lin Hu, Xue Li and Qiang-Sun Zheng

    Citation: BMC Cell Biology 2013 14:5

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  28. Content type: Research article

    Cadmium(Cd), a heavy metal, which has a potent harmful effects, is a highly stress-inducible material that is robustly expressed following disruption of homeostasis in the endoplasmic reticulum (ER) (so-called...

    Authors: Seungwoo Kim, Hyo-Soon Cheon, So-Young Kim, Yong-Sung Juhnn and Young-Youl Kim

    Citation: BMC Cell Biology 2013 14:4

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  29. Content type: Research article

    The mammalian target of rapamycin (mTOR) signalling pathway has a key role in cellular regulation and several diseases. While it is thought that Rheb GTPase regulates mTOR, acting immediately upstream, while r...

    Authors: Rahul B Yadav, Pierre Burgos, Anthony W Parker, Valentina Iadevaia, Christopher G Proud, Rodger A Allen, James P O'Connell, Ananya Jeshtadi, Christopher D Stubbs and Stanley W Botchway

    Citation: BMC Cell Biology 2013 14:3

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  30. Content type: Research article

    Disease manifestations of Staphylococcus aureus are connected to the fibronectin (Fn)-binding capacity of these Gram-positive pathogens. Fn deposition on the surface of S. aureus allows engagement of α5β1 integri...

    Authors: Marina Borisova, Yong Shi, Alexander Buntru, Susanne Wörner, Wolfgang H Ziegler and Christof R Hauck

    Citation: BMC Cell Biology 2013 14:2

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  31. Content type: Research article

    Hyperleptinemia is known to participate in cardiac hypertrophy and hypertension, but the relationship between pressure overload and leptin is poorly understood. We therefore examined the expression of leptin (...

    Authors: Hiroki Matsui, Tomoyuki Yokoyama, Chie Tanaka, Hiroaki Sunaga, Norimichi Koitabashi, Takako Takizawa, Masashi Arai and Masahiko Kurabayashi

    Citation: BMC Cell Biology 2012 13:37

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  32. Content type: Research article

    Telomeres are essential for the maintenance of genomic stability, and telomere dysfunction leads to cellular senescence, carcinogenesis, aging, and age-related diseases in humans. Pigs have become increasingly...

    Authors: Guangzhen Ji, Kai Liu, Maja Okuka, Na Liu and Lin Liu

    Citation: BMC Cell Biology 2012 13:36

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  33. Content type: Research article

    Induced pluripotent stem cells (iPSC) are generated by reprogramming somatic cells into embryonic like state (ESC) using defined factors. There is great interest in these cells because of their potential for a...

    Authors: Feng Li and Christopher Niyibizi

    Citation: BMC Cell Biology 2012 13:35

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  34. Content type: Research article

    Covalent modifications of proteins provide a mechanism to control protein function. Here, we have investigated modifications of the heptameric Sec complex which is responsible for post-translational protein im...

    Authors: Christina Soromani, Naiyan Zeng, Klaus Hollemeyer, Elmar Heinzle, Marie-Christine Klein, Thomas Tretter, Matthew N J Seaman and Karin Römisch

    Citation: BMC Cell Biology 2012 13:34

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  35. Content type: Research article

    Transient receptor potential canonical (TRPC) channels are non-selective cation channels involved in receptor-mediated calcium signaling in diverse cells and tissues. The canonical transient receptor potential...

    Authors: Robert Carrasquillo, Dequan Tian, Sneha Krishna, Martin R Pollak, Anna Greka and Johannes Schlöndorff

    Citation: BMC Cell Biology 2012 13:33

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  36. Content type: Research article

    Nucleolin is a protein over-expressed on the surface of activated cells. Recent studies have underlined the involvement of cell surface nucleolin in angiogenesis processes. This cell surface molecule serves as...

    Authors: Charalampos Birmpas, Jean Paul Briand, Josẻ Courty and Panagiotis Katsoris

    Citation: BMC Cell Biology 2012 13:32

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  37. Content type: Research article

    Mig2 has been described as a transcriptional factor that in the absence of Mig1 protein is required for glucose repression of the SUC2 gene. Recently it has been reported that Mig2 has two different subcellular l...

    Authors: Alejandra Fernández-Cid, Montserrat Vega, Pilar Herrero and Fernando Moreno

    Citation: BMC Cell Biology 2012 13:31

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  38. Content type: Research article

    AmpA is a secreted 24Kd protein that has pleiotropic effects onDictyostelium development. Null mutants delay development atthe mound stage with cells adhering too tightly to the substrate. Prestalkcells initially...

    Authors: Elizabeth F Noratel, Chere’ L Petty, Jessica S Kelsey, Hoa N Cost, Nisha Basappa and Daphne D Blumberg

    Citation: BMC Cell Biology 2012 13:29

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  39. Content type: Research article

    Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through the autophagosomal-lysosomal pathway. In skeletal muscle, autophagy has been regarded as a key ...

    Authors: Xiaokun Yu, Junfeng Ma, Feng Lin, Wanke Zhao, Xueqi Fu and Zhizhuang Joe Zhao

    Citation: BMC Cell Biology 2012 13:28

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  40. Content type: Research article

    The Dystrophin Glycoprotein Complex (DGC) is at the center of significant inheritable diseases, such as muscular dystrophies that can be fatal and impair neuronal function in addition to muscle degeneration. R...

    Authors: April K Marrone, Evgeniia V Edeleva, Mariya M Kucherenko, Nai-Hua Hsiao and Halyna R Shcherbata

    Citation: BMC Cell Biology 2012 13:26

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  41. Content type: Research article

    Ovarian cancer is one of the most lethal malignancies in women, as it is frequently detected at an advanced stage, and cancers often become refractory to chemotherapy. Evidence suggests that dysregulation of p...

    Authors: Uttara Saran, Frank Arfuso, Nikolajs Zeps and Arunasalam Dharmarajan

    Citation: BMC Cell Biology 2012 13:25

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  42. Content type: Research article

    One of the problems associated with osteosarcoma is the frequent formation of micrometastases in the lung prior to diagnosis because the development of metastatic lesions often causes a fatal outcome. Therefor...

    Authors: Atsushi Nakamura, Junichi Aizawa, Kenshi Sakayama, Teruki Kidani, Tomoyo Takata, Yoshiaki Norimatsu, Hiromasa Miura and Hiroshi Masuno

    Citation: BMC Cell Biology 2012 13:24

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  43. Content type: Research article

    Ovarian hyper stimulation syndrome (OHSS) is an iatrogenic complication associated with fertility drugs. It is characterized by increased vascular permeability and substantial fluid shift with accumulation in ...

    Authors: Pei-Yin Jin, Yong-Chao Lu, Ling Li and Qin-Fu Han

    Citation: BMC Cell Biology 2012 13:23

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  44. Content type: Research article

    In interferon-γ-stimulated cells, the dimeric transcription factor STAT1 (s ignal t ransducer and a ctivator of t ranscription 1) recognizes semi-palindromic motifs in the promoter regions of cytokine-driven targ...

    Authors: Verena Koch, Julia Staab, Volker Ruppert and Thomas Meyer

    Citation: BMC Cell Biology 2012 13:22

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  45. Content type: Research article

    Adipose tissues contain populations of pluripotent mesenchymal stem cells that also secrete various cytokines and growth factors to support repair of damaged tissues. In this study, we examined the role of oxi...

    Authors: Mariko Moriyama, Hiroyuki Moriyama, Ayaka Ueda, Yusuke Nishibata, Hanayuki Okura, Akihiro Ichinose, Akifumi Matsuyama and Takao Hayakawa

    Citation: BMC Cell Biology 2012 13:21

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