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  1. Content type: Research article

    The visceral musculature of Drosophila larvae comprises circular visceral muscles tightly interwoven with longitudinal visceral muscles. During myogenesis, the circular muscles arise by one-to-one fusion of a cir...

    Authors: Anja Rudolf, Detlev Buttgereit, Matthias Jacobs, Georg Wolfstetter, Dörthe Kesper, Michael Pütz, Susanne Berger, Renate Renkawitz-Pohl, Anne Holz and Susanne F Önel

    Citation: BMC Cell Biology 2014 15:27

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  2. Content type: Research article

    Nuclear Dbf-related/large tumor suppressor (NDR/LATS) kinases have been shown recently to control pathways that regulate mitotic exit, cytokinesis, cell growth, morphological changes and apoptosis. LATS kinase...

    Authors: Annette Müller-Taubenberger, Peter M Kastner, Michael Schleicher, Parvin Bolourani and Gerald Weeks

    Citation: BMC Cell Biology 2014 15:25

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  3. Content type: Research article

    Chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass in diabetes leading to reduced insulin secretion. Exposure to pro-inflammatory cytokines can stimulate apoptosis in pancreatic β-...

    Authors: Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath and Baggavalli P Somesh

    Citation: BMC Cell Biology 2014 15:24

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  4. Content type: Research article

    Clathrin-mediated vesicular trafficking, the mechanism by which proteins and lipids are transported between membrane-bound organelles, accounts for a large proportion of import from the plasma membrane (endocy...

    Authors: Ligia Cristina Kalb, Yohana Camila Antunes Frederico, Cassiano Martin Batista, Iriane Eger, Stênio Perdigão Fragoso and Maurilio José Soares

    Citation: BMC Cell Biology 2014 15:23

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  5. Content type: Research article

    Characterizing the nuclear orientation of chromosomes in the three-dimensional (3D) nucleus by multicolor banding (mBANDing) is a new approach towards understanding nuclear organization of chromosome territori...

    Authors: Ann-Kristin Schmälter, Alexandra Kuzyk, Christiaan H Righolt, Michaela Neusser, Ortrud K Steinlein, Stefan Müller and Sabine Mai

    Citation: BMC Cell Biology 2014 15:22

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  6. Content type: Research article

    Upon activation neutrophil releases microparticles - small plasma membrane vesicles that contain cell surface proteins and cytoplasmic matter, with biological activities. In this study we investigated the pote...

    Authors: Thassila Nogueira Pitanga, Luciana de Aragão França, Viviane Costa Junqueira Rocha, Thayna Meirelles, Valéria Matos Borges, Marilda Souza Gonçalves, Lain Carlos Pontes-de-Carvalho, Alberto Augusto Noronha-Dutra and Washington Luis Conrado dos-Santos

    Citation: BMC Cell Biology 2014 15:21

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  7. Content type: Research article

    Normal, healthy human breast tissue from a variety of volunteer donors has become available for research thanks to the establishment of the Susan G. Komen for the Cure® Tissue Bank at the IU Simon Cancer Cente...

    Authors: Candice AM Sauder, Jillian E Koziel, MiRan Choi, Melanie J Fox, Brenda R Grimes, Sunil Badve, Rachel J Blosser, Milan Radovich, Christina C Lam, Melville B Vaughan, Brittney-Shea Herbert and Susan E Clare

    Citation: BMC Cell Biology 2014 15:20

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  8. Content type: Research article

    Acacia honey is a natural product which has proven to have therapeutic effects on skin wound healing, but its potential healing effects in corneal wound healing have not been studied. This study aimed to explo...

    Authors: Choy Ker-Woon, Norzana Abd Ghafar, Chua Kien Hui and Yasmin Anum Mohd Yusof

    Citation: BMC Cell Biology 2014 15:19

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  9. Content type: Research article

    Polycomb Group (PcG) proteins are chromatin modifiers involved in early embryonic development as well as in proliferation of adult stem cells and cancer cells. PcG proteins form large repressive complexes term...

    Authors: Prasad Pethe, Punam Nagvenkar and Deepa Bhartiya

    Citation: BMC Cell Biology 2014 15:18

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  10. Content type: Research article

    Telomeres have crucial meiosis-specific roles in the orderly reduction of chromosome numbers and in ensuring the integrity of the genome during meiosis. One such role is the attachment of telomeres to trans-nu...

    Authors: Katrin Daniel, Daniel Tränkner, Lukasz Wojtasz, Hiroki Shibuya, Yoshinori Watanabe, Manfred Alsheimer and Attila Tóth

    Citation: BMC Cell Biology 2014 15:17

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  11. Content type: Research article

    Fibroblast Activation Protein alpha (FAP-α) or seprase is an integral membrane serine peptidase. Previous work has not satisfactorily explained both the suppression and promotion effects that have been observe...

    Authors: Jun Jia, Tracey Amanda Martin, Lin Ye and Wen Guo Jiang

    Citation: BMC Cell Biology 2014 15:16

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  12. Content type: Methodology article

    The domestic pig is an excellent animal model to study human microbial diseases due to its similarity to humans in terms of anatomy, physiology, and genetics. We assessed the suitability of an in vitro air-liquid...

    Authors: Mario Delgado-Ortega, Michel Olivier, Pierre-Yves Sizaret, Gaëlle Simon and François Meurens

    Citation: BMC Cell Biology 2014 15:14

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  13. Content type: Methodology article

    Some studies demonstrated therapeutic angiogenesis attributable to the effects of endothelial progenitor cells (EPC), others have reported disappointing results. This may be due to the fact that EPC population...

    Authors: Andreas Brandl, Quan Yuan, Anja M Boos, Justus P Beier, Andreas Arkudas, Ulrich Kneser, Raymund E Horch and Oliver Bleiziffer

    Citation: BMC Cell Biology 2014 15:12

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  14. Content type: Research article

    In vitro experiments on the functional roles of extracellular matrix (ECM) components usually involve the culture of cells on surfaces coated with purified ECM components. These experiments can seldom recupera...

    Authors: Sze Wing Tang, Wing Yin Tong, Wei Shen, Kelvin W K Yeung and Yun Wah Lam

    Citation: BMC Cell Biology 2014 15:10

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  15. Content type: Research article

    Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant cause of bone infection. Toll like receptors (TLRs) are an important segments of host response to infection and are expressed by a variety of ...

    Authors: Aparna Maiti and William A Jiranek

    Citation: BMC Cell Biology 2014 15:11

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  16. Content type: Research article

    Branched-chain amino acids, especially leucine, are known to interact with insulin signaling pathway and glucose metabolism. However, the mechanism by which this is exerted, remain to be clearly defined. In or...

    Authors: Barbara Di Camillo, Federica Eduati, Sreekumaran K Nair, Angelo Avogaro and Gianna M Toffolo

    Citation: BMC Cell Biology 2014 15:9

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  17. Content type: Research article

    Myosin IC is a single headed member of the myosin superfamily that localizes to the cytoplasm and the nucleus and is implicated in a variety of processes in both compartments. We recently identified a novel is...

    Authors: Neil L Sielski, Ivanna Ihnatovych, Jacob J Hagen and Wilma A Hofmann

    Citation: BMC Cell Biology 2014 15:8

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  18. Content type: Research article

    Recently, evidence indicated that the rapamycin-eluting stent which was used worldwide may contribute to an increased risk for thrombosis. On the contrary, other researchers found it was safe. Thus, it is nece...

    Authors: Ping Jiang, Yong Lan, Jun Luo, Ya-Li Ren, Dong-Ge Liu, Jian-Xin Pang, Jin Liu, Jian Li, Chen Wang and Jian-Ping Cai

    Citation: BMC Cell Biology 2014 15:7

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  19. Content type: Database

    Research antibodies are used by thousands of scientists working in diverse disciplines, but it is common to hear concerns about antibody quality. This means that researchers need to carefully choose the antibo...

    Authors: Matthew A Helsby, Paul M Leader, Joe R Fenn, Tulay Gulsen, Chris Bryant, Gail Doughton, Ben Sharpe, Paul Whitley, Christopher J Caunt, Katrina James, Adam D Pope, Dave H Kelly and Andrew D Chalmers

    Citation: BMC Cell Biology 2014 15:6

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  20. Content type: Research article

    In the setting of liver injury hepatic progenitor cells are activated, counterbalancing the inhibited regenerative capacity of mature hepatocytes. Chronic activation of this compartment may give rise to a subs...

    Authors: Gianmarco Villano, Cristian Turato, Santina Quarta, Mariagrazia Ruvoletto, Francesco Ciscato, Liliana Terrin, Rossella Semeraro, Claudia Paternostro, Maurizio Parola, Domenico Alvaro, Paolo Bernardi, Angelo Gatta and Patrizia Pontisso

    Citation: BMC Cell Biology 2014 15:5

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  21. Content type: Reviewer acknowledgement

    The editors of BMC Cell Biology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2013).

    Authors: Tim Sands

    Citation: BMC Cell Biology 2014 15:3

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  22. Content type: Research article

    Epigenetic regulation is known to affect gene expression, and recent research shows that aberrant DNA methylation patterning and histone modifications may play a role in leukemogenesis. In order to highlight t...

    Authors: Rūta Navakauskienė, Veronika V Borutinskaitė, Gražina Treigytė, Jūratė Savickienė, Dalius Matuzevičius, Dalius Navakauskas and Karl-Eric Magnusson

    Citation: BMC Cell Biology 2014 15:4

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  23. Content type: Research article

    Reduced muscle mass is a hallmark of metabolic diseases like diabetes and cancer. The mammalian (mechanistic) target of rapamycin complex 1/S6 kinase 1 (mTORC1/S6K1) pathway is critical to the regulation of mu...

    Authors: Dhanshri Kakade, Nushaba Islam, Naomi Maeda and Olasunkanmi A J Adegoke

    Citation: BMC Cell Biology 2014 15:2

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  24. Content type: Research article

    Diabetes and particularly high blood glucose levels are implicated in neurodegeneration. One of the hallmarks of neurodegeneration is protein aggregation. We investigated the presence of protein aggregation in...

    Authors: Fatemeh Talaei, Veroniek M Van Praag, Mahdi H Shishavan, Sjoerd W Landheer, Henk Buikema and Robert H Henning

    Citation: BMC Cell Biology 2014 15:1

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  25. Content type: Research article

    The entry of calcium ions into mammary gland epithelial cells is one of the least well-understood processes in the transport of calcium into milk during lactation. The store-operated calcium entry channel ORAI...

    Authors: Diana GF Ross, Chanel E Smart, Iman Azimi, Sarah J Roberts-Thomson and Gregory R Monteith

    Citation: BMC Cell Biology 2013 14:57

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  26. Content type: Research article

    The Sec61 channel mediates protein translocation across the endoplasmic reticulum (ER) membrane during secretory protein biogenesis, and likely also during export of misfolded proteins for ER-associated degrad...

    Authors: Thomas Tretter, Fábio P Pereira, Ozlem Ulucan, Volkhard Helms, Susanne Allan, Kai-Uwe Kalies and Karin Römisch

    Citation: BMC Cell Biology 2013 14:56

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  27. Content type: Research article

    A good in vitro model should approximate an in vivo-like behavior as closely as possible in order to reflect most likely the in vivo situation. Regarding renal physiology of different species, humans are more clo...

    Authors: Alexandra H Heussner and Daniel R Dietrich

    Citation: BMC Cell Biology 2013 14:55

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  28. Content type: Research article

    Mesenchymal stem cells have properties that make them amenable to therapeutic use. However, the acceptance of mesenchymal stem cells in clinical practice requires standardized techniques for their specific iso...

    Authors: Andrew Wetzig, Ayodele Alaiya, Monther Al-Alwan, Christian Benedict Pradez, Manogaran S Pulicat, Amer Al-Mazrou, Zakia Shinwari, Ghida Majed Sleiman, Hazem Ghebeh, Hind Al-Humaidan, Ameera Gaafar, Imaduddin Kanaan and Chaker Adra

    Citation: BMC Cell Biology 2013 14:54

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  29. Content type: Research article

    Regulation of anoikis in human intestinal epithelial cells (IECs) implicates differentiation state-specific mechanisms. Human IECs express distinct repertoires of integrins according to their state of differen...

    Authors: Marco Beauséjour, Sonya Thibodeau, Marie-Josée Demers, Véronique Bouchard, Rémy Gauthier, Jean-François Beaulieu and Pierre H Vachon

    Citation: BMC Cell Biology 2013 14:53

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  30. Content type: Research article

    BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched ...

    Authors: Babatunji W Ogunkolade, Tania A Jones, Johan Aarum, Jaroslaw Szary, Nicholas Owen, Diego Ottaviani, Muhammad A Mumin, Shyam Patel, Christopher A Pieri, Andrew R Silver and Denise Sheer

    Citation: BMC Cell Biology 2013 14:52

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  31. Content type: Research article

    THO (Suppressors of the transcriptional defects of hpr1 delta by overexpression) complex 5 (THOC5), an mRNA export protein, is involved in the expression of only 1% of all genes. Using an interferon inducible ...

    Authors: Shashank Saran, Doan DH Tran, Sabine Klebba-Färber, Patricia Moran-Losada, Lutz Wiehlmann, Alexandra Koch, Himpriya Chopra, Oliver Pabst, Andrea Hoffmann, Robert Klopfleisch and Teruko Tamura

    Citation: BMC Cell Biology 2013 14:51

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  32. Content type: Research article

    Acrosomal proteins play crucial roles in the physiology of fertilization. Identification of proteins localizing to the acrosome is fundamental to the understanding of its contribution to fertilization. Novel p...

    Authors: Rupa Bhattacharya, Manju S Devi, Vishnu M Dhople and Rachel A Jesudasan

    Citation: BMC Cell Biology 2013 14:50

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  33. Content type: Research article

    Integrin α6β4 contributes to cancer progression by stimulating transcription as well as translation of cancer related genes. Our previous study demonstrated that α6β4 stimulates translation initiation of survi...

    Authors: Young Hwa Soung, Nadejda Korneeva, Tae Hyong Kim and Jun Chung

    Citation: BMC Cell Biology 2013 14:49

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  34. Content type: Research article

    Multilineage differentiation, immunomodulation and secretion of trophic factors render mesenchymal stromal cells (MSC) highly attractive for clinical application. Human platelet derivatives such as pooled huma...

    Authors: Sven Kinzebach, Lisa Dietz, Harald Klüter, Hermann-Josef Thierse and Karen Bieback

    Citation: BMC Cell Biology 2013 14:48

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  35. Content type: Research article

    Bone fractures and loss represent significant costs for the public health system and often affect the patients quality of life, therefore, understanding the molecular basis for bone regeneration is essential. ...

    Authors: Erik Halcsik, Maria Fernanda Forni, Andre Fujita, Thiago Verano-Braga, Ole Nørregaard Jensen and Mari Cleide Sogayar

    Citation: BMC Cell Biology 2013 14:47

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  36. Content type: Research article

    Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a t...

    Authors: Gerben van Ooijen, Sarah F Martin, Martin E Barrios-Llerena, Matthew Hindle, Thierry Le Bihan, John S O'Neill and Andrew J Millar

    Citation: BMC Cell Biology 2013 14:46

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  37. Content type: Research article

    ADF/cofilin proteins are key modulators of actin dynamics in metastasis and invasion of cancer cells. Here we focused on the roles of ADF and cofilin-1 individually in the development of polarized migration of...

    Authors: Lubna H Tahtamouni, Alisa E Shaw, Maram H Hasan, Salem R Yasin and James R Bamburg

    Citation: BMC Cell Biology 2013 14:45

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  38. Content type: Research article

    Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type a...

    Authors: Kate Lawrenson, Maria Notaridou, Nathan Lee, Elizabeth Benjamin, Ian J Jacobs, Christopher Jones and Simon A Gayther

    Citation: BMC Cell Biology 2013 14:43

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  39. Content type: Research article

    A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks. There are on...

    Authors: Yue Cheng, Arthur Kwok Leung Cheung, Josephine Mun Yee Ko, Yee Peng Phoon, Pui Man Chiu, Paulisally Hau Yi Lo, Marian L Waterman and Maria Li Lung

    Citation: BMC Cell Biology 2013 14:44

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  40. Content type: Research article

    Epithelial tissues depend on intercellular homodimerization of E-cadherin and loss of E-cadherin is central to the epithelial to mesenchymal transition seen in multiple human diseases. Signaling pathways regul...

    Authors: Takashi Ohama, Lifu Wang, Erin M Griner and David L Brautigan

    Citation: BMC Cell Biology 2013 14:42

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  41. Content type: Research article

    Increased adipose thermogenesis is being considered as a strategy aimed at preventing or reversing obesity. Thus, regulation of the uncoupling protein 1 (UCP1) gene in human adipocytes is of significant intere...

    Authors: Maria Murholm, Marie S Isidor, Astrid L Basse, Sally Winther, Cathrine Sørensen, Jonas Skovgaard-Petersen, Maja M Nielsen, Aina S Hansen, Bjørn Quistorff and Jacob B Hansen

    Citation: BMC Cell Biology 2013 14:41

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  42. Content type: Research article

    Ischemic preconditioning has been proposed to involve changes in mitochondrial H+ and K+ fluxes, in particular through activation of uncoupling proteins and ATP-sensitive K+ channels (MitoKATP). The objectives of...

    Authors: Saori Morota, Sarah Piel and Magnus J Hansson

    Citation: BMC Cell Biology 2013 14:40

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  43. Content type: Research article

    Differentiation and fusion of skeletal muscle myoblasts into multi-nucleated myotubes is required for neonatal development and regeneration in adult skeletal muscle. Herein, we report novel findings that prote...

    Authors: Joseph S Marino, Terry D Hinds Jr., Rachael A Potter, Eric Ondrus, Jeremy L Onion, Abigail Dowling, Thomas J McLoughlin, Edwin R Sanchez and Jennifer W Hill

    Citation: BMC Cell Biology 2013 14:39

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  44. Content type: Research article

    Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of s...

    Authors: Yong Sook Kim, Jin Sook Kwon, Moon Hwa Hong, Wan Seok Kang, Hye-yun Jeong, Hye-jin Kang, Myung Ho Jeong and Youngkeun Ahn

    Citation: BMC Cell Biology 2013 14:38

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  45. Content type: Research article

    Previous research indicates that the membrane ruffles and leading edge of lamellipodia of myogenic cells contain presumptive fusion sites. A micrometer-sized lipid raft (microraft) is organized at the presumpt...

    Authors: Atsushi Mukai and Naohiro Hashimoto

    Citation: BMC Cell Biology 2013 14:37

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  46. Content type: Methodology article

    Tissue microenvironments comprise different extracellular matrix (ECM) proteins that regulate cellular responsiveness to growth factors. In vitro culture of adherent cells on ECM-coated substrata is commonly u...

    Authors: Iren Abrahamsen and James B Lorens

    Citation: BMC Cell Biology 2013 14:36

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  47. Content type: Methodology article

    Endolysosomes play a key role in maintaining the homeostasis of the cell. They are made of a complex set of proteins that degrade lipids, proteins and sugars. Studies involving endolysosome contribution to cel...

    Authors: Archana Vaithilingam, Nicole Y Lai, Ellen Duong, Julie Boucau, Yang Xu, Mariko Shimada, Malini Gandhi and Sylvie Le Gall

    Citation: BMC Cell Biology 2013 14:35

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  48. Content type: Research article

    Obesity is associated with a higher risk of developing cancer and co-morbidities that are part of the metabolic syndrome. Adipose tissue is recognized as an endocrine organ, as it affects a number of physiolog...

    Authors: Trivia P Frazier, Jeffrey M Gimble, Jessica W Devay, Hugh A Tucker, Ernest S Chiu and Brian G Rowan

    Citation: BMC Cell Biology 2013 14:34

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