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  1. Content type: Research article

    Seipin is required for the correct assembly of cytoplasmic lipid droplets. In the absence of the yeast seipin homolog Sei1p (formerly Fld1p), droplets are slow to bud from the endoplasmic reticulum, lack the n...

    Authors: Sungwon Han, Derk D. Binns, Yu-Fang Chang and Joel M. Goodman

    Citation: BMC Cell Biology 2015 16:29

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  2. Content type: Research article

    The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a r...

    Authors: Donatella Ponti, Daniela Bastianelli, Paolo Rosa, Luca Pacini, Mohsen Ibrahim, Erino Angelo Rendina, Giuseppe Ragona and Antonella Calogero

    Citation: BMC Cell Biology 2015 16:27

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  3. Content type: Research article

    The membrane anchored kinase, LMTK2, is a serine/threonine kinase predominantly localized to endosomal compartments. LMTK2 has been shown to be involved in the trafficking of the CFTR ion channel, the androgen...

    Authors: E. C. Butler and Neil A. Bradbury

    Citation: BMC Cell Biology 2015 16:26

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  4. Content type: Research article

    To analyze the ways and methods of signaling pathways in regulating cell cycle progression of NIH3T3 at transcriptional level, we modeled cell cycle of NIH3T3 and found that G1 phase of NIH3T3 cell cycle was a...

    Authors: Cuifang Chang, Zhipeng Niu, Ningning Gu, Weiming Zhao, Gaiping Wang, Yifeng Jia, Deming Li and Cunshuan Xu

    Citation: BMC Cell Biology 2015 16:25

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  5. Content type: Research article

    Endocytosis of activated EGF receptor (EGFR) to specific endocytic compartments is required to terminate EGF signaling. Trafficking of EGFR relies on microtubule tracks that transport the cargo vesicle to thei...

    Authors: Seung Joon Lee, Zhiqin Li, Alisa Litan, Soonmoon Yoo and Sigrid A. Langhans

    Citation: BMC Cell Biology 2015 16:24

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  6. Content type: Methodology article

    The traditional problems of performing skeletal muscle cell cultures derived from mammalian or avian species are limited myotube differentiation, and transient myotube persistence which greatly restricts the a...

    Authors: Sujith Sebastian, Leah Goulding, Suresh V. Kuchipudi and Kin-Chow Chang

    Citation: BMC Cell Biology 2015 16:23

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  7. Content type: Research article

    Environmental factors are important for stem cell lineage specification, and increasing evidence indicates that the nanoscale geometry/topography of the extracellular matrix (ECM) directs stem cell fate. Recen...

    Authors: Yan Chen, Di Zeng, Lu Ding, Xiao-Li Li, Xiong-Tao Liu, Wen-Ju Li, Ting Wei, Song Yan, Jiang-Hui Xie, Li Wei and Qiang-Sun Zheng

    Citation: BMC Cell Biology 2015 16:22

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  8. Content type: Research article

    Preeclampsia, one of the major disorders of pregnancy, is characterized by inadequate trophoblast invasion and defective trophoblast-mediated remodeling of placental vasculature. MicroRNA-34a (miR-34a) has bee...

    Authors: Manni Sun, Haiying Chen, Jing Liu, Chunxiao Tong and Tao Meng

    Citation: BMC Cell Biology 2015 16:21

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  9. Content type: Research article

    Recent studies have reported the roles of Hyaluronic acid (HA) chains of diverse length in wound repair, especially considering the simultaneous occurrence in vivo of both high- (H-HA) and low-molecular weight (L...

    Authors: Antonella D’Agostino, Antonietta Stellavato, Teresa Busico, Agata Papa, Virginia Tirino, Gianpaolo Papaccio, Annalisa La Gatta, Mario De Rosa and Chiara Schiraldi

    Citation: BMC Cell Biology 2015 16:19

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  10. Content type: Research article

    Cells contain several inositol pyrophosphates (PP-InsPs; also known as diphosphoinositol polyphosphates), which play pivotal roles in cellular and organismic homeostasis. It has been proposed that determining ...

    Authors: Sheila T. Yong, Hoai-Nghia Nguyen, Jae H. Choi, Carl D. Bortner, Jason Williams, Niyas K. Pulloor, Manoj N. Krishnan and Stephen B. Shears

    Citation: BMC Cell Biology 2015 16:17

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  11. Content type: Research article

    Previously published reports indicated that some enzymes of the central carbon metabolism (CCM), particularly those involved in glycolysis and the tricarboxylic acid cycle, may contribute to regulation of DNA ...

    Authors: Aleksandra Konieczna, Aneta Szczepańska, Karolina Sawiuk, Grzegorz Węgrzyn and Robert Łyżeń

    Citation: BMC Cell Biology 2015 16:16

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  12. Content type: Research article

    Polycystin-1 (PC-1) is a large plasma membrane receptor, encoded by the PKD1 gene, which is mutated in most cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The disease is characterized by renal cys...

    Authors: Maddalena Castelli, Chiara De Pascalis, Gianfranco Distefano, Nadia Ducano, Amanda Oldani, Letizia Lanzetti and Alessandra Boletta

    Citation: BMC Cell Biology 2015 16:15

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  13. Content type: Research article

    Optineurin is a gene associated with normal tension glaucoma and amyotrophic lateral sclerosis. It has been reported previously that in cultured RGC5 cells, the turnover of endogenous optineurin involves mainl...

    Authors: Hongyu Ying, Sanja Turturro, Tara Nguyen, Xiang Shen, Ruth Zelkha, Elaine C Johnson, John C Morrison and Beatrice YJT Yue

    Citation: BMC Cell Biology 2015 16:14

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  14. Content type: Research article

    Skeletal muscle differentiation is a multistep, complex pathway in which several important signaling molecules are involved. Recently, microRNAs (miRNAs), endogenous non-coding small RNAs that regulate mRNAs, ...

    Authors: Naoki Katase, Kumiko Terada, Takahiro Suzuki, Shin-ichiro Nishimatsu and Tsutomu Nohno

    Citation: BMC Cell Biology 2015 16:13

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    The Erratum to this article has been published in BMC Cell Biology 2016 17:9

  15. Content type: Methodology article

    Experimental models are inevitably a compromise between accurately reproducing a pathological situation and schematically simplifying it, which is intended to provide both relevance and conclusiveness. In-vivo mo...

    Authors: David Legouis, Aurélien Bataille, Alexandre Hertig, Sophie Vandermeersch, Noémie Simon, Eric Rondeau and Pierre Galichon

    Citation: BMC Cell Biology 2015 16:12

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  16. Content type: Reviewer acknowledgement

    The editors of BMC Cell Biology would like to thank all our reviewers who have contributed to the journal in Volume 15 (2014).

    Authors: Tim Sands

    Citation: BMC Cell Biology 2015 16:11

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  17. Content type: Research article

    In osteoporosis, bone loss is accompanied by increased marrow adiposity. Given their proximity in the bone marrow and their shared origin, a dialogue between adipocytes and osteoblasts could be a factor in the...

    Authors: Perrine J Martin, Nathalie Haren, Olfa Ghali, Aline Clabaut, Christophe Chauveau, Pierre Hardouin and Odile Broux

    Citation: BMC Cell Biology 2015 16:10

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  18. Content type: Methodology article

    Osteoblasts and adipocytes share a common mesenchymal stem cell origin. Therefore, it has been suggested that the accumulation of marrow adipocytes observed in bone loss is caused by a shift in the commitment ...

    Authors: Olfa Ghali, Odile Broux, Guillaume Falgayrac, Nathalie Haren, Johannes PTM van Leeuwen, Guillaume Penel, Pierre Hardouin and Christophe Chauveau

    Citation: BMC Cell Biology 2015 16:9

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  19. Content type: Research article

    There is evidence that several messenger RNAs (mRNAs) are bifunctional RNAs, i.e. RNA transcript carrying both protein-coding capacity and activity as functional non-coding RNA via 5′ and 3′ untranslated regions ...

    Authors: Hikaru Nagano, Naoko Yamagishi, Chisato Tomida, Chiaki Yano, Kana Aibara, Shohei Kohno, Tomoki Abe, Ayako Ohno, Katsuya Hirasaka, Yuushi Okumura, Edward M Mills, Takeshi Nikawa and Shigetada Teshima-Kondo

    Citation: BMC Cell Biology 2015 16:8

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  20. Content type: Research article

    Transforming growth factor-β1 (TGF-β1) plays a key role in mesothelial-to-mesenchymal transition (MMT) during peritoneal dialysis (PD). However, the role of Akt in MMT transformation in PD is not clear.

    Authors: Li Xiao, Xiang Peng, Fuyou Liu, Chengyuan Tang, Chun Hu, Xiaoxuan Xu, Ming Wang, Ying Luo, Shikun Yang, Panai Song, Ping Xiao, Yashpal S Kanwar and Lin Sun

    Citation: BMC Cell Biology 2015 16:7

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  21. Content type: Research article

    The growth properties and self-renewal capacity of embryonic stem (ES) cells are regulated by their immediate microenvironment such as the extracellular matrix (ECM). Integrins, a central family of cellular EC...

    Authors: Sandhanakrishnan Cattavarayane, Riitta Palovuori, Jayendrakishore Tanjore Ramanathan and Aki Manninen

    Citation: BMC Cell Biology 2015 16:3

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  22. Content type: Research article

    3C proteases, the main proteases of picornaviruses, play the key role in viral life cycle by processing polyproteins. In addition, 3C proteases digest certain host cell proteins to suppress antiviral defense, ...

    Authors: Andrey V Shubin, Ilya V Demidyuk, Nataliya A Lunina, Alexey A Komissarov, Marina P Roschina, Olga G Leonova and Sergey V Kostrov

    Citation: BMC Cell Biology 2015 16:4

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  23. Content type: Methodology article

    Biosynthetic trafficking of receptors and other membrane-associated proteins from the endoplasmic reticulum (ER) to the plasma membrane (PM) underlies the capacity of these proteins to participate in crucial c...

    Authors: Kirsten L Bryant, Barbara Baird and David Holowka

    Citation: BMC Cell Biology 2015 16:5

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  24. Content type: Research article

    Mps1, an essential component of the mitotic checkpoint, is also an important interphase regulator and has roles in DNA damage response, cytokinesis and centrosome duplication. Mps1 predominantly resides in the...

    Authors: Haiwei Jia, Xiaojuan Zhang, Wenjun Wang, Yuanyuan Bai, Youguo Ling, Cheng Cao, Runlin Z Ma, Hui Zhong, Xue Wang and Quanbin Xu

    Citation: BMC Cell Biology 2015 16:6

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  25. Content type: Research article

    Acacia honey (AH) has been proven to improve skin wound healing, but its therapeutic effects on corneal epithelium has not been elucidated to date. This study aimed to investigate the effects of AH on cultured...

    Authors: Choy Ker-Woon, Norzana Abd Ghafar, Chua Kien Hui, Yasmin Anum Mohd Yusof and Wan Zurinah Wan Ngah

    Citation: BMC Cell Biology 2015 16:2

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  26. Content type: Research article

    EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. The degradation of ERAD substrat...

    Authors: Iwona Sokołowska, Ewa S Piłka, Kirsten Sandvig, Grzegorz Węgrzyn and Monika Słomińska-Wojewódzka

    Citation: BMC Cell Biology 2015 16:1

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  27. Content type: Research article

    Mesenchymal stromal cells (MSC) can be obtained from potentially any tissue from the human body, but cells purified from different sources are undoubtedly different, and for each medical application, the MSC w...

    Authors: Paola Romina Amable, Marcus Vinicius Telles Teixeira, Rosana Bizon Vieira Carias, José Mauro Granjeiro and Radovan Borojevic

    Citation: BMC Cell Biology 2014 15:46

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  28. Content type: Research article

    Lipids are stored within cells in lipid droplets (LDs). They consist of a core of neutral lipids surrounded by a monolayer of phospholipids, predominantly phosphatidylcholine (PC). LDs are very dynamic and can...

    Authors: Christine Moessinger, Kristina Klizaite, Almut Steinhagen, Julia Philippou-Massier, Andrej Shevchenko, Michael Hoch, Christer S Ejsing and Christoph Thiele

    Citation: BMC Cell Biology 2014 15:43

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  29. Content type: Methodology article

    With the rapid advancement of cell biology, the evaluation of a given protein’s synthesis and release in cells becomes critical. However, up to now there has been no technique available to morphologically visu...

    Authors: Guowei Huang, Yun Wang, Juping Wang, Chunzhang Yang, Tao Huang, Zhengping Zhuang and Jiang Gu

    Citation: BMC Cell Biology 2014 15:45

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  30. Content type: Methodology

    Basement matrices such as Matrigel™ and Geltrex™ are used in a variety of cell culture assays of anchorage-dependent differentiation including endothelial cell tube formation assays. The volumes of matrix reco...

    Authors: Ashton Faulkner, Robert Purcell, Andrew Hibbert, Sally Latham, Scott Thomson, Wendy L Hall, Caroline Wheeler-Jones and David Bishop-Bailey

    Citation: BMC Cell Biology 2014 15:41

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  31. Content type: Methodology article

    Surface plasmon resonance imaging (SPRI) is a label-free technique that can image refractive index changes at an interface. We have previously used SPRI to study the dynamics of cell-substratum interactions. H...

    Authors: Alexander W Peterson, Michael Halter, Alessandro Tona and Anne L Plant

    Citation: BMC Cell Biology 2014 15:35

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  32. Content type: Methodology article

    Cnidarians are the closest living relatives to bilaterians and have been instrumental to studying the evolution of bilaterian properties. The cnidarian model, Nematostella vectensis, is a unique system in which e...

    Authors: Timothy Q DuBuc, Anna A Dattoli, Leslie S Babonis, Miguel Salinas-Saavedra, Eric Röttinger, Mark Q Martindale and Marten Postma

    Citation: BMC Cell Biology 2014 15:44

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  33. Content type: Methodology article

    Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated...

    Authors: Ye Zhao, Hong Zhao, Yun Zhang, Tania Tsatralis, Qi Cao, Ya Wang, Yiping Wang, Yuan Min Wang, Steve I Alexander, David C Harris and Guoping Zheng

    Citation: BMC Cell Biology 2014 15:40

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  34. Content type: Research article

    Mesenchymal stem cells (MSCs) have the potential to differentiate into specialized cell lineages such as osteoblasts and adipocytes in vitro. There exists a reciprocal relationship between osteogenic and adipogen...

    Authors: Sooho Lee, Hee-Yeon Cho, Hang Thi Thuy Bui and Dongchul Kang

    Citation: BMC Cell Biology 2014 15:42

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  35. Content type: Research article

    Neutrophils are a critical part of the innate immune system. Their ability to migrate into infected or injured tissues precedes their role in microbial killing and clearance. We have previously shown that Rab2...

    Authors: Rajesh K Singh, Rebecca C Furze, Mark A Birrell, Sara M Rankin, Alistair N Hume and Miguel C Seabra

    Citation: BMC Cell Biology 2014 15:39

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  36. Content type: Research article

    The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reporte...

    Authors: Héloise M Leclair, Sonia M Dubois, Sandy Azzi, Julie Dwyer, Nicolas Bidère and Julie Gavard

    Citation: BMC Cell Biology 2014 15:38

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  37. Content type: Research article

    Resistance to chemotherapy represents a major obstacle in correcting colorectal carcinomas (CRC). Inspite of recent advances in the treatment of metastatic disease, the prognosis of the patients remains poor. ...

    Authors: Asif Khurshid Qazi, Aashiq Hussain, Mushtaq A Aga, Shakir Ali, Subhash Chandra Taneja, Parduman Raj Sharma, Ajit Kumar Saxena, Dilip M Mondhe and Abid Hamid

    Citation: BMC Cell Biology 2014 15:36

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  38. Content type: Research article

    The bone marrow is a hematopoietic tissue that, in the presence of cytokines and growth factors, generates all of the circulating blood cells. These cells are important for protecting the organism against path...

    Authors: Bruno José Martins da Silva, Ana Paula D Rodrigues, Luis Henrique S Farias, Amanda Anastácia P Hage, Jose Luiz M Do Nascimento and Edilene O Silva

    Citation: BMC Cell Biology 2014 15:37

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  39. Content type: Research article

    The expression of 2′-5′-Oligoadenylate synthetases (OASs) is induced by type 1 Interferons (IFNs) in response to viral infection. The OAS proteins have a unique ability to produce 2′-5′ Oligoadenylates, which ...

    Authors: Karina Hansen Kjær, Jytte Pahus, Mariann Fagernæs Hansen, Jesper Buchhave Poulsen, Erik Ilsø Christensen, Just Justesen and Pia Møller Martensen

    Citation: BMC Cell Biology 2014 15:33

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  40. Content type: Research article

    In mammalian cells, ASPL is involved in insulin-stimulated redistribution of the glucose transporter GLUT4 and assembly of the Golgi apparatus. Its putative yeast orthologue, Ubx4, is important for proteasome ...

    Authors: Louise Madsen, Karen Molbæk, Ida B Larsen, Sofie V Nielsen, Esben G Poulsen, Peter S Walmod, Kay Hofmann, Michael Seeger, Chen-Ying Chien, Rey-Huei Chen, Franziska Kriegenburg and Rasmus Hartmann-Petersen

    Citation: BMC Cell Biology 2014 15:31

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  41. Content type: Research article

    Cullins belong to a family of scaffold proteins that assemble multi-subunit ubiquitin ligase complexes to recruit protein substrates for ubiquitination via unique sets of substrate adaptor, such as Skp1 or Elo...

    Authors: Wananit Wimuttisuk, Mark West, Brittney Davidge, Kebing Yu, Arthur Salomon and Jeffrey D Singer

    Citation: BMC Cell Biology 2014 15:28

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  42. Content type: Research article

    The Akita mutation (C96Y) in the insulin gene results in early onset diabetes in both humans and mice. Expression of mutant proinsulin (C96Y) causes endoplasmic reticulum (ER) stress in pancreatic β-cells and ...

    Authors: Liling Zhang, Courtney Nosak, Pietro Sollazzo, Tanya Odisho and Allen Volchuk

    Citation: BMC Cell Biology 2014 15:29

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  43. Content type: Review

    Live cell imaging enables the study of dynamic processes of living cells in real time by use of suitable reporter proteins and the staining of specific cellular structures and/or organelles. With the availabil...

    Authors: Sandeep Salipalli, Prafull Kumar Singh and Jürgen Borlak

    Citation: BMC Cell Biology 2014 15:26

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