Protein degradation and cell death

Protein degradation and cell death

Section edited by Xuejun Jiang

This section will consider submissions on cellular disease mechanisms, protein degradation, autophagy and cell death.

  1. Research article

    Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells

    Endophytes have proven to be an invaluable resource of chemically diverse secondary metabolites that act as excellent lead compounds for anticancer drug discovery. Here we report the promising cytotoxic effect...

    Mytre Koul, Ashok Kumar, Ramesh Deshidi, Vishal Sharma, Rachna D. Singh, Jasvinder Singh, Parduman Raj Sharma, Bhahwal Ali Shah, Sundeep Jaglan and Shashank Singh

    BMC Cell Biology 2017 18:26

    Published on: 20 July 2017

    The Erratum to this article has been published in BMC Cell Biology 2017 18:27

  2. Research article

    Microvesicles derived from hypoxia/reoxygenation-treated human umbilical vein endothelial cells promote apoptosis and oxidative stress in H9c2 cardiomyocytes

    Vascular endothelial dysfunction is the closely related determinant of ischemic heart disease (IHD). Endothelial dysfunction and ischemia/reperfusion injury (IRI) have been associated with an increase in micro...

    Qi Zhang, Man Shang, Mengxiao Zhang, Yao Wang, Yan Chen, Yanna Wu, Minglin Liu, Junqiu Song and Yanxia Liu

    BMC Cell Biology 2016 17:25

    Published on: 23 June 2016

  3. Research article

    Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect

    In mammalian cells, ASPL is involved in insulin-stimulated redistribution of the glucose transporter GLUT4 and assembly of the Golgi apparatus. Its putative yeast orthologue, Ubx4, is important for proteasome ...

    Louise Madsen, Karen Molbæk, Ida B Larsen, Sofie V Nielsen, Esben G Poulsen, Peter S Walmod, Kay Hofmann, Michael Seeger, Chen-Ying Chien, Rey-Huei Chen, Franziska Kriegenburg and Rasmus Hartmann-Petersen

    BMC Cell Biology 2014 15:31

    Published on: 31 July 2014

  4. Research article

    Novel Cul3 binding proteins function to remodel E3 ligase complexes

    Cullins belong to a family of scaffold proteins that assemble multi-subunit ubiquitin ligase complexes to recruit protein substrates for ubiquitination via unique sets of substrate adaptor, such as Skp1 or Elo...

    Wananit Wimuttisuk, Mark West, Brittney Davidge, Kebing Yu, Arthur Salomon and Jeffrey D Singer

    BMC Cell Biology 2014 15:28

    Published on: 10 July 2014

  5. Research article

    Increased protein aggregation in Zucker Diabetic Fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide

    Diabetes and particularly high blood glucose levels are implicated in neurodegeneration. One of the hallmarks of neurodegeneration is protein aggregation. We investigated the presence of protein aggregation in...

    Fatemeh Talaei, Veroniek M Van Praag, Mahdi H Shishavan, Sjoerd W Landheer, Henk Buikema and Robert H Henning

    BMC Cell Biology 2014 15:1

    Published on: 6 January 2014

  6. Research article

    Suppression of anoikis in human intestinal epithelial cells: differentiation state-selective roles of α2β1, α3β1, α5β1, and α6β4 integrins

    Regulation of anoikis in human intestinal epithelial cells (IECs) implicates differentiation state-specific mechanisms. Human IECs express distinct repertoires of integrins according to their state of differen...

    Marco Beauséjour, Sonya Thibodeau, Marie-Josée Demers, Véronique Bouchard, Rémy Gauthier, Jean-François Beaulieu and Pierre H Vachon

    BMC Cell Biology 2013 14:53

    Published on: 1 December 2013

  7. Research article

    Respiratory uncoupling by increased H+ or K+ flux is beneficial for heart mitochondrial turnover of reactive oxygen species but not for permeability transition

    Ischemic preconditioning has been proposed to involve changes in mitochondrial H+ and K+ fluxes, in particular through activation of uncoupling proteins and ATP-sensitive K+ channels (MitoKATP). The objectives of...

    Saori Morota, Sarah Piel and Magnus J Hansson

    BMC Cell Biology 2013 14:40

    Published on: 22 September 2013

  8. Methodology article

    A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells

    Endolysosomes play a key role in maintaining the homeostasis of the cell. They are made of a complex set of proteins that degrade lipids, proteins and sugars. Studies involving endolysosome contribution to cel...

    Archana Vaithilingam, Nicole Y Lai, Ellen Duong, Julie Boucau, Yang Xu, Mariko Shimada, Malini Gandhi and Sylvie Le Gall

    BMC Cell Biology 2013 14:35

    Published on: 9 August 2013

  9. Research article

    Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

    Apoptosis is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade responsible for executing cell death following cytochrome c release is well d...

    Matthew Brentnall, Luis Rodriguez-Menocal, Rebeka Ladron De Guevara, Enrique Cepero and Lawrence H Boise

    BMC Cell Biology 2013 14:32

    Published on: 9 July 2013

  10. Research article

    Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

    Two pathways are responsible for the majority of regulated protein catabolism in eukaryotic cells: the ubiquitin-proteasome system (UPS) and lysosomal self-degradation through autophagy. Both processes are nec...

    Péter Lőw, Ágnes Varga, Karolina Pircs, Péter Nagy, Zsuzsanna Szatmári, Miklós Sass and Gábor Juhász

    BMC Cell Biology 2013 14:29

    Published on: 25 June 2013

  11. Research article

    Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans

    Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through the autophagosomal-lysosomal pathway. In skeletal muscle, autophagy has been regarded as a key ...

    Xiaokun Yu, Junfeng Ma, Feng Lin, Wanke Zhao, Xueqi Fu and Zhizhuang Joe Zhao

    BMC Cell Biology 2012 13:28

    Published on: 31 October 2012

  12. Research article

    Unfertilized frog eggs die by apoptosis following meiotic exit

    A characteristic feature of frog reproduction is external fertilization accomplished outside the female's body. Mature fertilization-competent frog eggs are arrested at the meiotic metaphase II with high activ...

    Alexander A Tokmakov, Sho Iguchi, Tetsushi Iwasaki and Yasuo Fukami

    BMC Cell Biology 2011 12:56

    Published on: 23 December 2011

  13. Research article

    Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena

    The NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life. Recent studies have elucidated the importance of sirtuin activity ...

    Kristin M Slade, Sydney Freggiaro, Kyle A Cottrell, Joshua J Smith and Emily A Wiley

    BMC Cell Biology 2011 12:40

    Published on: 21 September 2011