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Nuclear function and transport

  1. Content type: Research article

    The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell cycle regulation in a broad spectrum of malignancies. Syndecan-1, however, also transloca...

    Authors: Tünde Szatmári, Filip Mundt, Ashish Kumar-Singh, Lena Möbus, Rita Ötvös, Anders Hjerpe and Katalin Dobra

    Citation: BMC Cell Biology 2017 18:34

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  2. Content type: Research article

    Environmental stress can affect the viability or fecundity of an organism. Environmental stressors may affect the genome or the proteome and can cause cellular distress by contributing to protein damage or mis...

    Authors: Katherine M. Sampuda, Mason Riley and Lynn Boyd

    Citation: BMC Cell Biology 2017 18:18

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  3. Content type: Research article

    Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural...

    Authors: Elizabeth R. Smith, Yue Meng, Robert Moore, Jeffrey D. Tse, Arn G. Xu and Xiang-Xi Xu

    Citation: BMC Cell Biology 2017 18:8

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  4. Content type: Research article

    The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is exte...

    Authors: Callinice D. Capo-chichi, Toni M. Yeasky, Elizabeth R. Smith and Xiang-Xi Xu

    Citation: BMC Cell Biology 2016 17:37

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    The Erratum to this article has been published in BMC Cell Biology 2017 18:1

  5. Content type: Research article

    To explore the relationship between spatial genome organization and gene expression in the interphase nucleus, we used a genomic imprinting model, which offers parental-specific gene expression. Using 3D FISH ...

    Authors: Yvette Lahbib-Mansais, Harmonie Barasc, Maria Marti-Marimon, Florence Mompart, Eddie Iannuccelli, David Robelin, Juliette Riquet and Martine Yerle-Bouissou

    Citation: BMC Cell Biology 2016 17:35

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  6. Content type: Research

    Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. ...

    Authors: David Dickerson, Marek Gierliński, Vijender Singh, Etsushi Kitamura, Graeme Ball, Tomoyuki U. Tanaka and Tom Owen-Hughes

    Citation: BMC Cell Biology 2016 17:33

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  7. Content type: Research article

    Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is prese...

    Authors: Ian Holt, Nguyen Thuy Duong, Qiuping Zhang, Le Thanh Lam, Caroline A. Sewry, Kamel Mamchaoui, Catherine M. Shanahan and Glenn E. Morris

    Citation: BMC Cell Biology 2016 17:26

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  8. Content type: Research article

    Ankyrin repeats and LEM domain containing protein 1 (Ankle1) belongs to the LEM protein family, whose members share a chromatin-interacting LEM motif. Unlike most other LEM proteins, Ankle1 is not an integral ...

    Authors: Livija Zlopasa, Andreas Brachner and Roland Foisner

    Citation: BMC Cell Biology 2016 17:23

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  9. Content type: Research article

    The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a r...

    Authors: Donatella Ponti, Daniela Bastianelli, Paolo Rosa, Luca Pacini, Mohsen Ibrahim, Erino Angelo Rendina, Giuseppe Ragona and Antonella Calogero

    Citation: BMC Cell Biology 2015 16:27

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  10. Content type: Research article

    BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched ...

    Authors: Babatunji W Ogunkolade, Tania A Jones, Johan Aarum, Jaroslaw Szary, Nicholas Owen, Diego Ottaviani, Muhammad A Mumin, Shyam Patel, Christopher A Pieri, Andrew R Silver and Denise Sheer

    Citation: BMC Cell Biology 2013 14:52

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  11. Content type: Research article

    While the essential role of 3D nuclear architecture on nuclear functions has been demonstrated for various cell types, information available for neutrophils, essential components of the immune system, remains ...

    Authors: Florence Mompart, David Robelin, Chantal Delcros and Martine Yerle-Bouissou

    Citation: BMC Cell Biology 2013 14:30

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  12. Content type: Research article

    Mig2 has been described as a transcriptional factor that in the absence of Mig1 protein is required for glucose repression of the SUC2 gene. Recently it has been reported that Mig2 has two different subcellular l...

    Authors: Alejandra Fernández-Cid, Montserrat Vega, Pilar Herrero and Fernando Moreno

    Citation: BMC Cell Biology 2012 13:31

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  13. Content type: Research article

    MeCP2 (CpG-binding protein 2) is a nuclear multifunctional protein involved in several cellular processes, like large-scale chromatin reorganization and architecture, and transcriptional regulation. In recent ...

    Authors: Federica Babbio, Ilaria Castiglioni, Chiara Cassina, Marzia Bruna Gariboldi, Christian Pistore, Elena Magnani, Gianfranco Badaracco, Elena Monti and Ian Marc Bonapace

    Citation: BMC Cell Biology 2012 13:19

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  14. Content type: Research article

    Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma derived from skeletal muscle precursor cells, which accounts for 5-8% of all childhood malignancies. Disseminated RMS represents a major clinical obsta...

    Authors: Steven J Wolf, Tony Huynh, Nicole S Bryce, Trevor W Hambley, Laurence PG Wakelin, Bernard W Stewart and Daniel R Catchpoole

    Citation: BMC Cell Biology 2011 12:36

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  15. Content type: Research article

    Nucleolus is the most prominent mammalian organelle within the nucleus which is also the site for ribosomal biogenesis. There have been many reports indicating the involvement of nucleolus in the process of ag...

    Authors: Bishnupriya kar, Baohua Liu, Zhongjun Zhou and Yun W Lam

    Citation: BMC Cell Biology 2011 12:33

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  16. Content type: Research article

    DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein. TorA appears to possess a nuclear envel...

    Authors: Michael T Jungwirth, Dhivya Kumar, Danielle Y Jeong and Rose E Goodchild

    Citation: BMC Cell Biology 2011 12:24

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