Cell signaling pathways and networks

This section will consider submissions on cell signaling, cell-cell interaction, second messenger systems and receptor-mediated signaling.

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  1. Research article

    Loss of pericyte smoothened activity in mice with genetic deficiency of leptin

    Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy avail...

    Guanhua Xie, Marzena Swiderska-Syn, Mark L. Jewell, Mariana Verdelho Machado, Gregory A. Michelotti, Richard T. Premont and Anna Mae Diehl

    BMC Cell Biology 2017 18:20

    Published on: 20 April 2017

  2. Research article

    Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells

    The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be...

    Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning and Stian Knappskog

    BMC Cell Biology 2017 18:17

    Published on: 17 April 2017

  3. Research article

    miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway

    MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regul...

    Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang and Lin Liu

    BMC Cell Biology 2017 18:9

    Published on: 17 January 2017

  4. Research article

    Early changes in the metabolic profile of activated CD8+ T cells

    Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accompl...

    Clemens Cammann, Alexander Rath, Udo Reichl, Holger Lingel, Monika Brunner-Weinzierl, Luca Simeoni, Burkhart Schraven and Jonathan A. Lindquist

    BMC Cell Biology 2016 17:28

    Published on: 7 July 2016

  5. Research article

    Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells

    Endothelial-mesenchymal transition (EndoMT) is a major source of myofibroblast formation in kidney fibrosis. Our previous study showed a profibrotic role for matrix metalloproteinase 9 (MMP-9) in kidney fibros...

    Ye Zhao, Xi Qiao, Lihua Wang, Tian Kui Tan, Hong Zhao, Yun Zhang, Jianlin Zhang, Padmashree Rao, Qi Cao, Yiping Wang, Ya Wang, Yuan Min Wang, Vincent W. S. Lee, Stephen I. Alexander, David C. H. Harris and Guoping Zheng

    BMC Cell Biology 2016 17:21

    Published on: 29 April 2016

  6. Research article

    Control of CXCR2 activity through its ubiquitination on K327 residue

    The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reporte...

    Héloise M Leclair, Sonia M Dubois, Sandy Azzi, Julie Dwyer, Nicolas Bidère and Julie Gavard

    BMC Cell Biology 2014 15:38

    Published on: 22 October 2014

  7. Research article

    Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function

    Chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass in diabetes leading to reduced insulin secretion. Exposure to pro-inflammatory cytokines can stimulate apoptosis in pancreatic β-...

    Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath and Baggavalli P Somesh

    BMC Cell Biology 2014 15:24

    Published on: 30 June 2014

  8. Research article

    Inhibition of Methicillin-resistant Staphylococcus aureus-induced cytokines mRNA production in human bone marrow derived mesenchymal stem cells by 1,25-dihydroxyvitamin D3

    Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant cause of bone infection. Toll like receptors (TLRs) are an important segments of host response to infection and are expressed by a variety of ...

    Aparna Maiti and William A Jiranek

    BMC Cell Biology 2014 15:11

    Published on: 25 March 2014

  9. Research article

    Leucine modulates dynamic phosphorylation events in insulin signaling pathway and enhances insulin-dependent glycogen synthesis in human skeletal muscle cells

    Branched-chain amino acids, especially leucine, are known to interact with insulin signaling pathway and glucose metabolism. However, the mechanism by which this is exerted, remain to be clearly defined. In or...

    Barbara Di Camillo, Federica Eduati, Sreekumaran K Nair, Angelo Avogaro and Gianna M Toffolo

    BMC Cell Biology 2014 15:9

    Published on: 20 March 2014

  10. Research article

    Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling

    Recently, evidence indicated that the rapamycin-eluting stent which was used worldwide may contribute to an increased risk for thrombosis. On the contrary, other researchers found it was safe. Thus, it is nece...

    Ping Jiang, Yong Lan, Jun Luo, Ya-Li Ren, Dong-Ge Liu, Jian-Xin Pang, Jin Liu, Jian Li, Chen Wang and Jian-Ping Cai

    BMC Cell Biology 2014 15:7

    Published on: 24 February 2014

  11. Database

    CiteAb: a searchable antibody database that ranks antibodies by the number of times they have been cited

    Research antibodies are used by thousands of scientists working in diverse disciplines, but it is common to hear concerns about antibody quality. This means that researchers need to carefully choose the antibo...

    Matthew A Helsby, Paul M Leader, Joe R Fenn, Tulay Gulsen, Chris Bryant, Gail Doughton, Ben Sharpe, Paul Whitley, Christopher J Caunt, Katrina James, Adam D Pope, Dave H Kelly and Andrew D Chalmers

    BMC Cell Biology 2014 15:6

    Published on: 14 February 2014

  12. Research article

    The role of c-Src in integrin (α6β4) dependent translational control

    Integrin α6β4 contributes to cancer progression by stimulating transcription as well as translation of cancer related genes. Our previous study demonstrated that α6β4 stimulates translation initiation of survi...

    Young Hwa Soung, Nadejda Korneeva, Tae Hyong Kim and Jun Chung

    BMC Cell Biology 2013 14:49

    Published on: 1 November 2013

  13. Research article

    Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga

    Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a t...

    Gerben van Ooijen, Sarah F Martin, Martin E Barrios-Llerena, Matthew Hindle, Thierry Le Bihan, John S O'Neill and Andrew J Millar

    BMC Cell Biology 2013 14:46

    Published on: 15 October 2013

  14. Research article

    Suppression of protein kinase C theta contributes to enhanced myogenesis In vitro via IRS1 and ERK1/2 phosphorylation

    Differentiation and fusion of skeletal muscle myoblasts into multi-nucleated myotubes is required for neonatal development and regeneration in adult skeletal muscle. Herein, we report novel findings that prote...

    Joseph S Marino, Terry D Hinds Jr., Rachael A Potter, Eric Ondrus, Jeremy L Onion, Abigail Dowling, Thomas J McLoughlin, Edwin R Sanchez and Jennifer W Hill

    BMC Cell Biology 2013 14:39

    Published on: 21 September 2013

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