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BMC Cell Biology

Cell signaling pathways and networks

This section will consider submissions on cell signaling, cell-cell interaction, second messenger systems and receptor-mediated signaling.

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  1. Content type: Research article

    Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy avail...

    Authors: Guanhua Xie, Marzena Swiderska-Syn, Mark L. Jewell, Mariana Verdelho Machado, Gregory A. Michelotti, Richard T. Premont and Anna Mae Diehl

    Citation: BMC Cell Biology 2017 18:20

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  2. Content type: Research article

    The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be...

    Authors: Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning and Stian Knappskog

    Citation: BMC Cell Biology 2017 18:17

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  3. Content type: Research article

    MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regul...

    Authors: Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang and Lin Liu

    Citation: BMC Cell Biology 2017 18:9

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  4. Content type: Research article

    The serine/threonine kinase PAK1 is an important regulator of cell motility. Both PAK1 and the hormone/cytokine prolactin (PRL) have been implicated in breast cancer cell motility, however, the exact mechanism...

    Authors: Alan Hammer and Maria Diakonova

    Citation: BMC Cell Biology 2016 17:31

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  5. Content type: Research article

    Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accompl...

    Authors: Clemens Cammann, Alexander Rath, Udo Reichl, Holger Lingel, Monika Brunner-Weinzierl, Luca Simeoni, Burkhart Schraven and Jonathan A. Lindquist

    Citation: BMC Cell Biology 2016 17:28

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  6. Content type: Research article

    Endothelial-mesenchymal transition (EndoMT) is a major source of myofibroblast formation in kidney fibrosis. Our previous study showed a profibrotic role for matrix metalloproteinase 9 (MMP-9) in kidney fibros...

    Authors: Ye Zhao, Xi Qiao, Lihua Wang, Tian Kui Tan, Hong Zhao, Yun Zhang, Jianlin Zhang, Padmashree Rao, Qi Cao, Yiping Wang, Ya Wang, Yuan Min Wang, Vincent W. S. Lee, Stephen I. Alexander, David C. H. Harris and Guoping Zheng

    Citation: BMC Cell Biology 2016 17:21

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  7. Content type: Research article

    Endocytosis of activated EGF receptor (EGFR) to specific endocytic compartments is required to terminate EGF signaling. Trafficking of EGFR relies on microtubule tracks that transport the cargo vesicle to thei...

    Authors: Seung Joon Lee, Zhiqin Li, Alisa Litan, Soonmoon Yoo and Sigrid A. Langhans

    Citation: BMC Cell Biology 2015 16:24

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  8. Content type: Research article

    The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reporte...

    Authors: Héloise M Leclair, Sonia M Dubois, Sandy Azzi, Julie Dwyer, Nicolas Bidère and Julie Gavard

    Citation: BMC Cell Biology 2014 15:38

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  9. Content type: Research article

    Chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass in diabetes leading to reduced insulin secretion. Exposure to pro-inflammatory cytokines can stimulate apoptosis in pancreatic β-...

    Authors: Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath and Baggavalli P Somesh

    Citation: BMC Cell Biology 2014 15:24

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  10. Content type: Research article

    Fibroblast Activation Protein alpha (FAP-α) or seprase is an integral membrane serine peptidase. Previous work has not satisfactorily explained both the suppression and promotion effects that have been observe...

    Authors: Jun Jia, Tracey Amanda Martin, Lin Ye and Wen Guo Jiang

    Citation: BMC Cell Biology 2014 15:16

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  11. Content type: Research article

    Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant cause of bone infection. Toll like receptors (TLRs) are an important segments of host response to infection and are expressed by a variety of ...

    Authors: Aparna Maiti and William A Jiranek

    Citation: BMC Cell Biology 2014 15:11

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  12. Content type: Research article

    Branched-chain amino acids, especially leucine, are known to interact with insulin signaling pathway and glucose metabolism. However, the mechanism by which this is exerted, remain to be clearly defined. In or...

    Authors: Barbara Di Camillo, Federica Eduati, Sreekumaran K Nair, Angelo Avogaro and Gianna M Toffolo

    Citation: BMC Cell Biology 2014 15:9

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  13. Content type: Research article

    Recently, evidence indicated that the rapamycin-eluting stent which was used worldwide may contribute to an increased risk for thrombosis. On the contrary, other researchers found it was safe. Thus, it is nece...

    Authors: Ping Jiang, Yong Lan, Jun Luo, Ya-Li Ren, Dong-Ge Liu, Jian-Xin Pang, Jin Liu, Jian Li, Chen Wang and Jian-Ping Cai

    Citation: BMC Cell Biology 2014 15:7

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  14. Content type: Database

    Research antibodies are used by thousands of scientists working in diverse disciplines, but it is common to hear concerns about antibody quality. This means that researchers need to carefully choose the antibo...

    Authors: Matthew A Helsby, Paul M Leader, Joe R Fenn, Tulay Gulsen, Chris Bryant, Gail Doughton, Ben Sharpe, Paul Whitley, Christopher J Caunt, Katrina James, Adam D Pope, Dave H Kelly and Andrew D Chalmers

    Citation: BMC Cell Biology 2014 15:6

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  15. Content type: Research article

    Reduced muscle mass is a hallmark of metabolic diseases like diabetes and cancer. The mammalian (mechanistic) target of rapamycin complex 1/S6 kinase 1 (mTORC1/S6K1) pathway is critical to the regulation of mu...

    Authors: Dhanshri Kakade, Nushaba Islam, Naomi Maeda and Olasunkanmi A J Adegoke

    Citation: BMC Cell Biology 2014 15:2

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  16. Content type: Research article

    Integrin α6β4 contributes to cancer progression by stimulating transcription as well as translation of cancer related genes. Our previous study demonstrated that α6β4 stimulates translation initiation of survi...

    Authors: Young Hwa Soung, Nadejda Korneeva, Tae Hyong Kim and Jun Chung

    Citation: BMC Cell Biology 2013 14:49

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  17. Content type: Research article

    Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a t...

    Authors: Gerben van Ooijen, Sarah F Martin, Martin E Barrios-Llerena, Matthew Hindle, Thierry Le Bihan, John S O'Neill and Andrew J Millar

    Citation: BMC Cell Biology 2013 14:46

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  18. Content type: Research article

    Differentiation and fusion of skeletal muscle myoblasts into multi-nucleated myotubes is required for neonatal development and regeneration in adult skeletal muscle. Herein, we report novel findings that prote...

    Authors: Joseph S Marino, Terry D Hinds Jr., Rachael A Potter, Eric Ondrus, Jeremy L Onion, Abigail Dowling, Thomas J McLoughlin, Edwin R Sanchez and Jennifer W Hill

    Citation: BMC Cell Biology 2013 14:39

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2016 Journal Metrics

  • Citation Impact
    2.405 - 2-year Impact Factor
    2.768 - 5-year Impact Factor
    0.836 - Source Normalized Impact per Paper (SNIP)
    1.351 - SCImago Journal Rank (SJR)

    Usage 
    311,604 Downloads
    1136.5 Usage Factor

    Social Media Impact
    38 Mentions

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