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Cell signaling pathways and networks

This section will consider submissions on cell signaling, cell-cell interaction, second messenger systems and receptor-mediated signaling.

  1. Content type: Research article

    Disruption to the blood brain barrier (BBB) is a leading factor associated with the development of postoperative cognitive dysfunction (POCD). Despite this, the underlying mechanism by which BBB disruption pro...

    Authors: Honghua Zhu, Wei Liu and Hao Fang

    Citation: BMC Cell Biology 2018 19:23

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  2. Content type: Research article

    Tendinopathies are common and difficult to resolve due to the formation of scar tissue that reduces the mechanical integrity of the tissue, leading to frequent reinjury. Tenocytes respond to both excessive loa...

    Authors: Anne E. C. Nichols, Robert E. Settlage, Stephen R. Werre and Linda A. Dahlgren

    Citation: BMC Cell Biology 2018 19:14

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  3. Content type: Research article

    Copines are calcium-dependent phospholipid-binding proteins found in many eukaryotic organisms and are thought to be involved in signaling pathways that regulate a wide variety of cellular processes. Copines a...

    Authors: April N. Ilacqua, Janet E. Price, Bria N. Graham, Matthew J. Buccilli, Dexter R. McKellar and Cynthia K. Damer

    Citation: BMC Cell Biology 2018 19:13

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  4. Content type: Research article

    Adipocyte differentiation of human mesenchymal stem cells (hMSCs) is dependent on mitochondrial metabolism and reactive oxygen species (ROS) to initiate adipocyte differentiation. Although anethole has been kn...

    Authors: Yun-Hee Rhee, Jeong Hwan Moon, Ji-Hun Mo, Tiffany Pham and Phil-Sang Chung

    Citation: BMC Cell Biology 2018 19:12

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  5. Content type: Research article

    Cellular energy failure in high metabolic rate organs is one of the underlying causes for many disorders such as neurodegenerative diseases, cardiomyopathies, liver and renal failures. In the past decade, nume...

    Authors: Shohreh Majd, John H. T. Power, Timothy K. Chataway and Hugh J. M. Grantham

    Citation: BMC Cell Biology 2018 19:7

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  6. Content type: Research article

    Rho guanine exchange factors (RhoGEFs) control cellular processes such as migration, adhesion and proliferation. Alternative splicing of the RhoGEF Trio produces TGAT. The RhoGEF TGAT is an oncoprotein with co...

    Authors: J. van Unen, D. Botman, T. Yin, Y. I. Wu, M. A. Hink, T. W. J. Gadella Jr, M. Postma and J. Goedhart

    Citation: BMC Cell Biology 2018 19:6

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  7. Content type: Research article

    Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage. Recovery from injury requires repair, an energy-expensive process that is coupled to energy avail...

    Authors: Guanhua Xie, Marzena Swiderska-Syn, Mark L. Jewell, Mariana Verdelho Machado, Gregory A. Michelotti, Richard T. Premont and Anna Mae Diehl

    Citation: BMC Cell Biology 2017 18:20

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  8. Content type: Research article

    The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be...

    Authors: Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning and Stian Knappskog

    Citation: BMC Cell Biology 2017 18:17

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  9. Content type: Research article

    MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regul...

    Authors: Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang and Lin Liu

    Citation: BMC Cell Biology 2017 18:9

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  10. Content type: Research article

    The serine/threonine kinase PAK1 is an important regulator of cell motility. Both PAK1 and the hormone/cytokine prolactin (PRL) have been implicated in breast cancer cell motility, however, the exact mechanism...

    Authors: Alan Hammer and Maria Diakonova

    Citation: BMC Cell Biology 2016 17:31

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  11. Content type: Research article

    Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accompl...

    Authors: Clemens Cammann, Alexander Rath, Udo Reichl, Holger Lingel, Monika Brunner-Weinzierl, Luca Simeoni, Burkhart Schraven and Jonathan A. Lindquist

    Citation: BMC Cell Biology 2016 17:28

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  12. Content type: Research article

    Endothelial-mesenchymal transition (EndoMT) is a major source of myofibroblast formation in kidney fibrosis. Our previous study showed a profibrotic role for matrix metalloproteinase 9 (MMP-9) in kidney fibros...

    Authors: Ye Zhao, Xi Qiao, Lihua Wang, Tian Kui Tan, Hong Zhao, Yun Zhang, Jianlin Zhang, Padmashree Rao, Qi Cao, Yiping Wang, Ya Wang, Yuan Min Wang, Vincent W. S. Lee, Stephen I. Alexander, David C. H. Harris and Guoping Zheng

    Citation: BMC Cell Biology 2016 17:21

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  13. Content type: Research article

    Endocytosis of activated EGF receptor (EGFR) to specific endocytic compartments is required to terminate EGF signaling. Trafficking of EGFR relies on microtubule tracks that transport the cargo vesicle to thei...

    Authors: Seung Joon Lee, Zhiqin Li, Alisa Litan, Soonmoon Yoo and Sigrid A. Langhans

    Citation: BMC Cell Biology 2015 16:24

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  14. Content type: Research article

    The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reporte...

    Authors: Héloise M Leclair, Sonia M Dubois, Sandy Azzi, Julie Dwyer, Nicolas Bidère and Julie Gavard

    Citation: BMC Cell Biology 2014 15:38

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  15. Content type: Research article

    Chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass in diabetes leading to reduced insulin secretion. Exposure to pro-inflammatory cytokines can stimulate apoptosis in pancreatic β-...

    Authors: Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Aggunda N Yateesh, Korrapati Neelima, Srikanth Mrudula, Madhusudhan Reddy, Rachapalli Smitha, Sanghamitra Biswas, Bhawna Chandravanshi, Puttrevana M Pallavi, Anup M Oommen, Madanahalli R Jagannath and Baggavalli P Somesh

    Citation: BMC Cell Biology 2014 15:24

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  16. Content type: Research article

    Fibroblast Activation Protein alpha (FAP-α) or seprase is an integral membrane serine peptidase. Previous work has not satisfactorily explained both the suppression and promotion effects that have been observe...

    Authors: Jun Jia, Tracey Amanda Martin, Lin Ye and Wen Guo Jiang

    Citation: BMC Cell Biology 2014 15:16

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  17. Content type: Research article

    Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant cause of bone infection. Toll like receptors (TLRs) are an important segments of host response to infection and are expressed by a variety of ...

    Authors: Aparna Maiti and William A Jiranek

    Citation: BMC Cell Biology 2014 15:11

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  18. Content type: Research article

    Branched-chain amino acids, especially leucine, are known to interact with insulin signaling pathway and glucose metabolism. However, the mechanism by which this is exerted, remain to be clearly defined. In or...

    Authors: Barbara Di Camillo, Federica Eduati, Sreekumaran K Nair, Angelo Avogaro and Gianna M Toffolo

    Citation: BMC Cell Biology 2014 15:9

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  19. Content type: Research article

    Recently, evidence indicated that the rapamycin-eluting stent which was used worldwide may contribute to an increased risk for thrombosis. On the contrary, other researchers found it was safe. Thus, it is nece...

    Authors: Ping Jiang, Yong Lan, Jun Luo, Ya-Li Ren, Dong-Ge Liu, Jian-Xin Pang, Jin Liu, Jian Li, Chen Wang and Jian-Ping Cai

    Citation: BMC Cell Biology 2014 15:7

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  20. Content type: Database

    Research antibodies are used by thousands of scientists working in diverse disciplines, but it is common to hear concerns about antibody quality. This means that researchers need to carefully choose the antibo...

    Authors: Matthew A Helsby, Paul M Leader, Joe R Fenn, Tulay Gulsen, Chris Bryant, Gail Doughton, Ben Sharpe, Paul Whitley, Christopher J Caunt, Katrina James, Adam D Pope, Dave H Kelly and Andrew D Chalmers

    Citation: BMC Cell Biology 2014 15:6

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  21. Content type: Research article

    Reduced muscle mass is a hallmark of metabolic diseases like diabetes and cancer. The mammalian (mechanistic) target of rapamycin complex 1/S6 kinase 1 (mTORC1/S6K1) pathway is critical to the regulation of mu...

    Authors: Dhanshri Kakade, Nushaba Islam, Naomi Maeda and Olasunkanmi A J Adegoke

    Citation: BMC Cell Biology 2014 15:2

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  22. Content type: Research article

    Integrin α6β4 contributes to cancer progression by stimulating transcription as well as translation of cancer related genes. Our previous study demonstrated that α6β4 stimulates translation initiation of survi...

    Authors: Young Hwa Soung, Nadejda Korneeva, Tae Hyong Kim and Jun Chung

    Citation: BMC Cell Biology 2013 14:49

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  23. Content type: Research article

    Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a t...

    Authors: Gerben van Ooijen, Sarah F Martin, Martin E Barrios-Llerena, Matthew Hindle, Thierry Le Bihan, John S O'Neill and Andrew J Millar

    Citation: BMC Cell Biology 2013 14:46

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  24. Content type: Research article

    Differentiation and fusion of skeletal muscle myoblasts into multi-nucleated myotubes is required for neonatal development and regeneration in adult skeletal muscle. Herein, we report novel findings that prote...

    Authors: Joseph S Marino, Terry D Hinds Jr., Rachael A Potter, Eric Ondrus, Jeremy L Onion, Abigail Dowling, Thomas J McLoughlin, Edwin R Sanchez and Jennifer W Hill

    Citation: BMC Cell Biology 2013 14:39

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  25. Content type: Methodology article

    Tissue microenvironments comprise different extracellular matrix (ECM) proteins that regulate cellular responsiveness to growth factors. In vitro culture of adherent cells on ECM-coated substrata is commonly u...

    Authors: Iren Abrahamsen and James B Lorens

    Citation: BMC Cell Biology 2013 14:36

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  26. Content type: Research article

    The transcription factor E2F4 controls proliferation of normal and cancerous intestinal epithelial cells. E2F4 localization in normal human intestinal epithelial cells (HIEC) is cell cycle-dependent, being cyt...

    Authors: Marie-Christine Paquin, Sébastien Cagnol, Julie C Carrier, Caroline Leblanc and Nathalie Rivard

    Citation: BMC Cell Biology 2013 14:33

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  27. Content type: Research article

    In the progression towards diabetes, glucolipotoxicity is one of the main causes of pancreatic beta cell pathology. The aim of this study was to examine the in vitro effects of chronic glucolipotoxic conditions o...

    Authors: Baggavalli P Somesh, Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Anup Mammen-Oommen, Sanghamitra Biswas, Pavagada C Shilpa, Ashok Kumar Reddy, Aggunda N Yateesh, Puttrevana M Pallavi, Siddaraju Nethra, Rachapalli Smitha, Korrapati Neelima, Usha Narayanan and Madanahalli R Jagannath

    Citation: BMC Cell Biology 2013 14:31

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  28. Content type: Research article

    The transition of epithelial cells from their normal non-motile state to a motile one requires the coordinated action of a number of small GTPases. We have previously shown that epithelial cell migration is st...

    Authors: Myriam A Attar and Lorraine C Santy

    Citation: BMC Cell Biology 2013 14:9

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  29. Content type: Research article

    Rap proteins belong to the Ras family of small G-proteins. Dictyostelium RapA is essential and implicated in processes throughout the life cycle. In early development and chemotaxis competent cells RapA induces p...

    Authors: Katarzyna Plak, Douwe Veltman, Fabrizia Fusetti, Jetze Beeksma, Francisco Rivero, Peter JM Van Haastert and Arjan Kortholt

    Citation: BMC Cell Biology 2013 14:6

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  30. Content type: Research article

    The mammalian target of rapamycin (mTOR) signalling pathway has a key role in cellular regulation and several diseases. While it is thought that Rheb GTPase regulates mTOR, acting immediately upstream, while r...

    Authors: Rahul B Yadav, Pierre Burgos, Anthony W Parker, Valentina Iadevaia, Christopher G Proud, Rodger A Allen, James P O'Connell, Ananya Jeshtadi, Christopher D Stubbs and Stanley W Botchway

    Citation: BMC Cell Biology 2013 14:3

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  31. Content type: Research article

    Hyperleptinemia is known to participate in cardiac hypertrophy and hypertension, but the relationship between pressure overload and leptin is poorly understood. We therefore examined the expression of leptin (...

    Authors: Hiroki Matsui, Tomoyuki Yokoyama, Chie Tanaka, Hiroaki Sunaga, Norimichi Koitabashi, Takako Takizawa, Masashi Arai and Masahiko Kurabayashi

    Citation: BMC Cell Biology 2012 13:37

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  32. Content type: Research article

    Transient receptor potential canonical (TRPC) channels are non-selective cation channels involved in receptor-mediated calcium signaling in diverse cells and tissues. The canonical transient receptor potential...

    Authors: Robert Carrasquillo, Dequan Tian, Sneha Krishna, Martin R Pollak, Anna Greka and Johannes Schlöndorff

    Citation: BMC Cell Biology 2012 13:33

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  33. Content type: Research article

    The Dystrophin Glycoprotein Complex (DGC) is at the center of significant inheritable diseases, such as muscular dystrophies that can be fatal and impair neuronal function in addition to muscle degeneration. R...

    Authors: April K Marrone, Evgeniia V Edeleva, Mariya M Kucherenko, Nai-Hua Hsiao and Halyna R Shcherbata

    Citation: BMC Cell Biology 2012 13:26

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  34. Content type: Research article

    Ovarian cancer is one of the most lethal malignancies in women, as it is frequently detected at an advanced stage, and cancers often become refractory to chemotherapy. Evidence suggests that dysregulation of p...

    Authors: Uttara Saran, Frank Arfuso, Nikolajs Zeps and Arunasalam Dharmarajan

    Citation: BMC Cell Biology 2012 13:25

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  35. Content type: Research article

    In interferon-γ-stimulated cells, the dimeric transcription factor STAT1 (s ignal t ransducer and a ctivator of t ranscription 1) recognizes semi-palindromic motifs in the promoter regions of cytokine-driven targ...

    Authors: Verena Koch, Julia Staab, Volker Ruppert and Thomas Meyer

    Citation: BMC Cell Biology 2012 13:22

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  36. Content type: Research article

    Transforming growth factor-beta 1 (TGF-β1) has been implicated in hyperoxia-induced cell death and impaired alveolarization in the developing lung. In addition, the c-JunNH2-terminal kinase (JNK) pathway has b...

    Authors: Zhang Li, Rayman Choo-Wing, Huanxing Sun, Angara Sureshbabu, Reiko Sakurai, Virender K Rehan and Vineet Bhandari

    Citation: BMC Cell Biology 2011 12:54

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  37. Content type: Research article

    SOX4 is a developmental transcription factor that is required for differentiation and proliferation in multiple tissues. SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer...

    Authors: Yu-Heng Lai, Jessica Cheng, Dongmei Cheng, Mattie E Feasel, Kyle D Beste, Junmin Peng, Asma Nusrat and Carlos S Moreno

    Citation: BMC Cell Biology 2011 12:50

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  38. Content type: Research article

    The Notch signalling pathway is conserved in pre-bilaterian animals. In the Cnidarian Hydra it is involved in interstitial stem cell differentiation and in boundary formation during budding. Experimental evidence...

    Authors: Andrea Prexl, Sandra Münder, Bernhard Loy, Elisabeth Kremmer, Susanne Tischer and Angelika Böttger

    Citation: BMC Cell Biology 2011 12:38

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  39. Content type: Research article

    Stanniocalcin 2 (STC2) is a secreted protein activated by (PKR)-like Endoplasmic Reticulum Kinase (PERK) signalling under conditions of ER stress in vitro. Over-expression of STC2 in mice leads to a growth-restri...

    Authors: Elena N Fazio, Gabriel E DiMattia, Sami A Chadi, Kristin D Kernohan and Christopher L Pin

    Citation: BMC Cell Biology 2011 12:17

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