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Cell differentiation and proliferation

This section will consider submissions with a focus on cell culture, growth and differentiation, including stem and germ cells, multipotency and tumor invasion.

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  1. Content type: Research article

    The palmitate analogue 2-bromopalmitate (2-BP) is a non-selective membrane tethered cysteine alkylator of many membrane-associated enzymes that in the last years emerged as a general inhibitor of protein S-pal...

    Authors: Cassiano Martin Batista, Rafael Luis Kessler, Iriane Eger and Maurilio José Soares

    Citation: BMC Cell Biology 2018 19:19

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  2. Content type: Research article

    Conditional reprogramming has enabled the development of long-lived, normal epithelial cell lines from mice and humans by in vitro culture with ROCK inhibitor on a feeder layer. We applied this technology to m...

    Authors: Emily C. Moorefield, R. Eric Blue, Nancy L. Quinney, Martina Gentzsch and Shengli Ding

    Citation: BMC Cell Biology 2018 19:15

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  3. Content type: Research article

    Air-liquid interface (Ali) systems allow the establishment of a culture environment more representative of that in vivo than other culture systems. They are useful for performing mechanistic studies of respira...

    Authors: Haiyan Wang, Lina He, Beibei Liu, Yanyan Feng, Hao Zhou, Zhenzhen Zhang, Yuzi Wu, Jia Wang, Yuan Gan, Ting Yuan, Meng Wu, Xing Xie and Zhixin Feng

    Citation: BMC Cell Biology 2018 19:10

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  4. Content type: Research article

    Contactin1 (CNTN1) has been shown to play an important role in the invasion and metastasis of several tumors; however, the role of CNTN1 in breast cancer has not been fully studied. The purpose of this study i...

    Authors: Nan Chen, Sai He, Jie Geng, Zhang-Jun Song, Pi-Hua Han, Juan Qin, Zheng Zhao, Yong-Chun Song, Hu-Xia Wang and Cheng-Xue Dang

    Citation: BMC Cell Biology 2018 19:5

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  5. Content type: Methodology article

    Mesenchymal stromal cells (MSCs) become an attractive research topic because of their crucial roles in tissue repair and regenerative medicine. Foreskin is considered as a valuable tissue source containing imm...

    Authors: Mehdi Najar, Emerence Crompot, Leo A. van Grunsven, Laurent Dollé and Laurence Lagneaux

    Citation: BMC Cell Biology 2018 19:4

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  6. Content type: Research article

    Satellite cells (SC) and their descendants, muscle precursor cells (MPC), play a key role in postnatal muscle development, regeneration, and plasticity. Several studies have provided evidence that SC and MPC r...

    Authors: Claudia Miersch, Katja Stange and Monika Röntgen

    Citation: BMC Cell Biology 2018 19:2

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  7. Content type: Research article

    Carcinoma associated fibroblasts (CAFs or myofibroblasts) are activated fibroblasts which participate in breast tumor growth, angiogenesis, invasion, metastasis and therapy resistance. As such, recent efforts ...

    Authors: Kathryn Woods, Catlyn Thigpen, Jennifer Peyling Wang, Hana Park and Abigail Hielscher

    Citation: BMC Cell Biology 2017 18:35

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  8. Content type: Research article

    Self-renewal and differentiation of embryonic stem cells (ESCs) is directed by biological and/or physical cues that regulate multiple signaling cascades. We have previously shown that mESCs seeded in a type I ...

    Authors: Olesja Hazenbiller, Neil A. Duncan and Roman J. Krawetz

    Citation: BMC Cell Biology 2017 18:32

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  9. Content type: Methodology article

    Generalized methods for understanding the cell biology of non-model species are quite rare, yet very much needed. In order to address this issue, we have modified a technique traditionally used in the biomedic...

    Authors: Benyamin Rosental, Zhanna Kozhekbaeva, Nathaniel Fernhoff, Jonathan M. Tsai and Nikki Traylor-Knowles

    Citation: BMC Cell Biology 2017 18:30

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  10. Content type: Research article

    Cartilage degradation is the significant pathological process in osteoarthritis (OA). Inflammatory cytokines, such as interleukin-1β (IL-1β), activate various downstream mediators contributing to OA pathology....

    Authors: Hao Wu, Zhanhai Yin, Ling Wang, Feng Li and Yusheng Qiu

    Citation: BMC Cell Biology 2017 18:29

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  11. Content type: Research article

    Biomaterials are widely used to regenerate or substitute bone tissue. In order to evaluate their potential use for clinical applications, these need to be tested and evaluated in vitro with cell culture models...

    Authors: Raquel Núñez-Toldrà, Ester Martínez-Sarrà, Carlos Gil-Recio, Miguel Ángel Carrasco, Ashraf Al Madhoun, Sheyla Montori and Maher Atari

    Citation: BMC Cell Biology 2017 18:21

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  12. Content type: Research article

    External root resorption, commonly starting from cementum, is a severe side effect of orthodontic treatment. In this pathological process and repairing course followed, cementoblasts play a significant role. P...

    Authors: Yuyu Li, Zhiai Hu, Chenchen Zhou, Yang Xu, Li Huang, Xin Wang and Shujuan Zou

    Citation: BMC Cell Biology 2017 18:19

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  13. Content type: Research article

    Volumetric muscle loss caused by trauma or after tumour surgery exceeds the natural regeneration capacity of skeletal muscle. Hence, the future goal of tissue engineering (TE) is the replacement and repair of ...

    Authors: R. Witt, A. Weigand, A. M. Boos, A. Cai, D. Dippold, A. R. Boccaccini, D. W. Schubert, M. Hardt, C. Lange, A. Arkudas, R. E. Horch and J. P. Beier

    Citation: BMC Cell Biology 2017 18:15

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  14. Content type: Research article

    Cell-based therapy is a treatment method in tendon injuries. Bone morphogenic protein 12 (BMP-12) possesses tenogenic activity and was proposed as a differentiating factor for stem cells directed to transplant...

    Authors: Weronika Zarychta-Wiśniewska, Anna Burdzinska, Agnieszka Kulesza, Kamila Gala, Beata Kaleta, Katarzyna Zielniok, Katarzyna Siennicka, Marek Sabat and Leszek Paczek

    Citation: BMC Cell Biology 2017 18:13

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  15. Content type: Research article

    Dental pulp stem cells (DPSCs) are increasingly being recognized as a viable cell source for regenerative medicine. Although significant variations in their ex vivo expansion are well-established, DPSC prolife...

    Authors: Amr Alraies, Nadia Y. A. Alaidaroos, Rachel J. Waddington, Ryan Moseley and Alastair J. Sloan

    Citation: BMC Cell Biology 2017 18:12

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  16. Content type: Research article

    To cause an economically important blast disease on rice, the filamentous fungus Magnaporthe oryzae forms a specialized infection structure, called an appressorium, to penetrate host cells. Once inside host cells...

    Authors: Emma N. Shipman, Kiersun Jones, Cory B. Jenkinson, Dong Won Kim, Jie Zhu and Chang Hyun Khang

    Citation: BMC Cell Biology 2017 18:11

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  17. Content type: Research article

    Sprouting angiogenesis requires vascular endothelial proliferation, migration and morphogenesis. The process is regulated by soluble factors, principally vascular endothelial growth factor (VEGF), and via bidi...

    Authors: M. Jarad, E. A. Kuczynski, J. Morrison, A. M. Viloria-Petit and B. L. Coomber

    Citation: BMC Cell Biology 2017 18:10

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  18. Content type: Methodology article

    Karyotypic integrity is essential for the successful germline transmission of alleles mutated in embryonic stem (ES) cells. Classical methods for the identification of aneuploidy involve cytological analyses t...

    Authors: Gemma F. Codner, Loic Lindner, Adam Caulder, Marie Wattenhofer-Donzé, Adam Radage, Annelyse Mertz, Benjamin Eisenmann, Joffrey Mianné, Edward P. Evans, Colin V. Beechey, Martin D. Fray, Marie-Christine Birling, Yann Hérault, Guillaume Pavlovic and Lydia Teboul

    Citation: BMC Cell Biology 2016 17:30

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  19. Content type: Research article

    IL-27 is a multifunctional cytokine that has both pro-inflammatory and anti-inflammatory functions. Although IL-27 has been shown to potently inhibit lung fibrosis, the detailed mechanism of IL-27 in this proc...

    Authors: Zhaoxing Dong, Wenlin Tai, Wen Lei, Yin Wang, ZhenKun Li and Tao Zhang

    Citation: BMC Cell Biology 2016 17:7

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  20. Content type: Methodology article

    The traditional problems of performing skeletal muscle cell cultures derived from mammalian or avian species are limited myotube differentiation, and transient myotube persistence which greatly restricts the a...

    Authors: Sujith Sebastian, Leah Goulding, Suresh V. Kuchipudi and Kin-Chow Chang

    Citation: BMC Cell Biology 2015 16:23

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  21. Content type: Research article

    Environmental factors are important for stem cell lineage specification, and increasing evidence indicates that the nanoscale geometry/topography of the extracellular matrix (ECM) directs stem cell fate. Recen...

    Authors: Yan Chen, Di Zeng, Lu Ding, Xiao-Li Li, Xiong-Tao Liu, Wen-Ju Li, Ting Wei, Song Yan, Jiang-Hui Xie, Li Wei and Qiang-Sun Zheng

    Citation: BMC Cell Biology 2015 16:22

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  22. Content type: Research article

    Preeclampsia, one of the major disorders of pregnancy, is characterized by inadequate trophoblast invasion and defective trophoblast-mediated remodeling of placental vasculature. MicroRNA-34a (miR-34a) has bee...

    Authors: Manni Sun, Haiying Chen, Jing Liu, Chunxiao Tong and Tao Meng

    Citation: BMC Cell Biology 2015 16:21

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  23. Content type: Research article

    Mesenchymal stromal cells (MSC) can be obtained from potentially any tissue from the human body, but cells purified from different sources are undoubtedly different, and for each medical application, the MSC w...

    Authors: Paola Romina Amable, Marcus Vinicius Telles Teixeira, Rosana Bizon Vieira Carias, José Mauro Granjeiro and Radovan Borojevic

    Citation: BMC Cell Biology 2014 15:46

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  24. Content type: Methodology

    Basement matrices such as Matrigel™ and Geltrex™ are used in a variety of cell culture assays of anchorage-dependent differentiation including endothelial cell tube formation assays. The volumes of matrix reco...

    Authors: Ashton Faulkner, Robert Purcell, Andrew Hibbert, Sally Latham, Scott Thomson, Wendy L Hall, Caroline Wheeler-Jones and David Bishop-Bailey

    Citation: BMC Cell Biology 2014 15:41

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  25. Content type: Methodology article

    Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated...

    Authors: Ye Zhao, Hong Zhao, Yun Zhang, Tania Tsatralis, Qi Cao, Ya Wang, Yiping Wang, Yuan Min Wang, Steve I Alexander, David C Harris and Guoping Zheng

    Citation: BMC Cell Biology 2014 15:40

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  26. Content type: Research article

    Mesenchymal stem cells (MSCs) have the potential to differentiate into specialized cell lineages such as osteoblasts and adipocytes in vitro. There exists a reciprocal relationship between osteogenic and adipogen...

    Authors: Sooho Lee, Hee-Yeon Cho, Hang Thi Thuy Bui and Dongchul Kang

    Citation: BMC Cell Biology 2014 15:42

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  27. Content type: Research article

    Resistance to chemotherapy represents a major obstacle in correcting colorectal carcinomas (CRC). Inspite of recent advances in the treatment of metastatic disease, the prognosis of the patients remains poor. ...

    Authors: Asif Khurshid Qazi, Aashiq Hussain, Mushtaq A Aga, Shakir Ali, Subhash Chandra Taneja, Parduman Raj Sharma, Ajit Kumar Saxena, Dilip M Mondhe and Abid Hamid

    Citation: BMC Cell Biology 2014 15:36

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  28. Content type: Research article

    The bone marrow is a hematopoietic tissue that, in the presence of cytokines and growth factors, generates all of the circulating blood cells. These cells are important for protecting the organism against path...

    Authors: Bruno José Martins da Silva, Ana Paula D Rodrigues, Luis Henrique S Farias, Amanda Anastácia P Hage, Jose Luiz M Do Nascimento and Edilene O Silva

    Citation: BMC Cell Biology 2014 15:37

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  29. Content type: Research article

    Acacia honey is a natural product which has proven to have therapeutic effects on skin wound healing, but its potential healing effects in corneal wound healing have not been studied. This study aimed to explo...

    Authors: Choy Ker-Woon, Norzana Abd Ghafar, Chua Kien Hui and Yasmin Anum Mohd Yusof

    Citation: BMC Cell Biology 2014 15:19

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  30. Content type: Research article

    Polycomb Group (PcG) proteins are chromatin modifiers involved in early embryonic development as well as in proliferation of adult stem cells and cancer cells. PcG proteins form large repressive complexes term...

    Authors: Prasad Pethe, Punam Nagvenkar and Deepa Bhartiya

    Citation: BMC Cell Biology 2014 15:18

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  31. Content type: Methodology article

    The domestic pig is an excellent animal model to study human microbial diseases due to its similarity to humans in terms of anatomy, physiology, and genetics. We assessed the suitability of an in vitro air-liquid...

    Authors: Mario Delgado-Ortega, Michel Olivier, Pierre-Yves Sizaret, Gaëlle Simon and François Meurens

    Citation: BMC Cell Biology 2014 15:14

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  32. Content type: Methodology article

    Some studies demonstrated therapeutic angiogenesis attributable to the effects of endothelial progenitor cells (EPC), others have reported disappointing results. This may be due to the fact that EPC population...

    Authors: Andreas Brandl, Quan Yuan, Anja M Boos, Justus P Beier, Andreas Arkudas, Ulrich Kneser, Raymund E Horch and Oliver Bleiziffer

    Citation: BMC Cell Biology 2014 15:12

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  33. Content type: Research article

    In the setting of liver injury hepatic progenitor cells are activated, counterbalancing the inhibited regenerative capacity of mature hepatocytes. Chronic activation of this compartment may give rise to a subs...

    Authors: Gianmarco Villano, Cristian Turato, Santina Quarta, Mariagrazia Ruvoletto, Francesco Ciscato, Liliana Terrin, Rossella Semeraro, Claudia Paternostro, Maurizio Parola, Domenico Alvaro, Paolo Bernardi, Angelo Gatta and Patrizia Pontisso

    Citation: BMC Cell Biology 2014 15:5

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  34. Content type: Research article

    Epigenetic regulation is known to affect gene expression, and recent research shows that aberrant DNA methylation patterning and histone modifications may play a role in leukemogenesis. In order to highlight t...

    Authors: Rūta Navakauskienė, Veronika V Borutinskaitė, Gražina Treigytė, Jūratė Savickienė, Dalius Matuzevičius, Dalius Navakauskas and Karl-Eric Magnusson

    Citation: BMC Cell Biology 2014 15:4

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  35. Content type: Research article

    A good in vitro model should approximate an in vivo-like behavior as closely as possible in order to reflect most likely the in vivo situation. Regarding renal physiology of different species, humans are more clo...

    Authors: Alexandra H Heussner and Daniel R Dietrich

    Citation: BMC Cell Biology 2013 14:55

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  36. Content type: Research article

    Mesenchymal stem cells have properties that make them amenable to therapeutic use. However, the acceptance of mesenchymal stem cells in clinical practice requires standardized techniques for their specific iso...

    Authors: Andrew Wetzig, Ayodele Alaiya, Monther Al-Alwan, Christian Benedict Pradez, Manogaran S Pulicat, Amer Al-Mazrou, Zakia Shinwari, Ghida Majed Sleiman, Hazem Ghebeh, Hind Al-Humaidan, Ameera Gaafar, Imaduddin Kanaan and Chaker Adra

    Citation: BMC Cell Biology 2013 14:54

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  37. Content type: Research article

    THO (Suppressors of the transcriptional defects of hpr1 delta by overexpression) complex 5 (THOC5), an mRNA export protein, is involved in the expression of only 1% of all genes. Using an interferon inducible ...

    Authors: Shashank Saran, Doan DH Tran, Sabine Klebba-Färber, Patricia Moran-Losada, Lutz Wiehlmann, Alexandra Koch, Himpriya Chopra, Oliver Pabst, Andrea Hoffmann, Robert Klopfleisch and Teruko Tamura

    Citation: BMC Cell Biology 2013 14:51

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  38. Content type: Research article

    Multilineage differentiation, immunomodulation and secretion of trophic factors render mesenchymal stromal cells (MSC) highly attractive for clinical application. Human platelet derivatives such as pooled huma...

    Authors: Sven Kinzebach, Lisa Dietz, Harald Klüter, Hermann-Josef Thierse and Karen Bieback

    Citation: BMC Cell Biology 2013 14:48

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  39. Content type: Research article

    Bone fractures and loss represent significant costs for the public health system and often affect the patients quality of life, therefore, understanding the molecular basis for bone regeneration is essential. ...

    Authors: Erik Halcsik, Maria Fernanda Forni, Andre Fujita, Thiago Verano-Braga, Ole Nørregaard Jensen and Mari Cleide Sogayar

    Citation: BMC Cell Biology 2013 14:47

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  40. Content type: Research article

    Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type a...

    Authors: Kate Lawrenson, Maria Notaridou, Nathan Lee, Elizabeth Benjamin, Ian J Jacobs, Christopher Jones and Simon A Gayther

    Citation: BMC Cell Biology 2013 14:43

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  41. Content type: Research article

    A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks. There are on...

    Authors: Yue Cheng, Arthur Kwok Leung Cheung, Josephine Mun Yee Ko, Yee Peng Phoon, Pui Man Chiu, Paulisally Hau Yi Lo, Marian L Waterman and Maria Li Lung

    Citation: BMC Cell Biology 2013 14:44

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  42. Content type: Research article

    Increased adipose thermogenesis is being considered as a strategy aimed at preventing or reversing obesity. Thus, regulation of the uncoupling protein 1 (UCP1) gene in human adipocytes is of significant intere...

    Authors: Maria Murholm, Marie S Isidor, Astrid L Basse, Sally Winther, Cathrine Sørensen, Jonas Skovgaard-Petersen, Maja M Nielsen, Aina S Hansen, Bjørn Quistorff and Jacob B Hansen

    Citation: BMC Cell Biology 2013 14:41

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  43. Content type: Research article

    Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of s...

    Authors: Yong Sook Kim, Jin Sook Kwon, Moon Hwa Hong, Wan Seok Kang, Hye-yun Jeong, Hye-jin Kang, Myung Ho Jeong and Youngkeun Ahn

    Citation: BMC Cell Biology 2013 14:38

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  44. Content type: Research article

    Obesity is associated with a higher risk of developing cancer and co-morbidities that are part of the metabolic syndrome. Adipose tissue is recognized as an endocrine organ, as it affects a number of physiolog...

    Authors: Trivia P Frazier, Jeffrey M Gimble, Jessica W Devay, Hugh A Tucker, Ernest S Chiu and Brian G Rowan

    Citation: BMC Cell Biology 2013 14:34

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  45. Content type: Research article

    Renal podocytes form the main filtration barrier possessing a unique phenotype maintained by proteins including podocalyxin and nephrin, the expression of which is suppressed in pathological conditions. We use...

    Authors: Nikolaos E Tsotakos, Marina Sagnou, Eleni S Kotsopoulou, Effie C Tsilibary and Garyfalia I Drossopoulou

    Citation: BMC Cell Biology 2013 14:28

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  46. Content type: Research article

    H19 is a paternally imprinted gene that has been shown to be highly expressed in the trophoblast tissue. Results from previous studies have initiated a debate as to whether noncoding RNA H19 acts as a tumor suppr...

    Authors: Li-Li Yu, Kai Chang, Lin-Shan Lu, Dan Zhao, Jian Han, Ying-Ru Zheng, Yao-Hua Yan, Ping Yi, Jian-Xin Guo, Yuan-Guo Zhou, Ming Chen and Li Li

    Citation: BMC Cell Biology 2013 14:26

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  47. Content type: Research article

    We have recently characterized two distinct populations of Satellite Cells (SCs) that differ in proliferation, regenerative potential, and mitochondrial coupling efficiency and classified these in Low Prolifer...

    Authors: Andrea Repele, Ramona Lupi, Simon Eaton, Luca Urbani, Paolo De Coppi and Michelangelo Campanella

    Citation: BMC Cell Biology 2013 14:24

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  48. Content type: Research article

    Krabbe disease, also known as globoid cell leukodystrophy, is an autosomal recessive neurodegenerative disease caused by the genetic deficiency of galactocerebrosidase (GALC), a lysosomal enzyme responsible fo...

    Authors: Xiujuan Zhang, Julie A Semon, Shijia Zhang, Amy L Strong, Brittni A Scruggs, Jeffrey M Gimble and Bruce A Bunnell

    Citation: BMC Cell Biology 2013 14:20

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