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BMC Cell Biology

Open Access

Erratum to: Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis

  • Callinice D. Capo-chichi1, 2, 3,
  • Toni M. Yeasky1, 2,
  • Elizabeth R. Smith1, 2 and
  • Xiang-Xi Xu1, 2Email author
BMC Cell BiologyBMC series – open, inclusive and trusted201718:1

https://doi.org/10.1186/s12860-016-0124-6

Received: 12 December 2016

Accepted: 21 December 2016

Published: 9 January 2017

The original article was published in BMC Cell Biology 2016 17:37

Erratum

This article [1] contains an updated version of Fig. 5. The original version has been corrected due to errors introduced during the process of illustration. The updated figure is also shown on the following page:
Fig. 5

Working model: nuclear envelope defect is the main cause of aneuploidy in carcinogenesis. a Depiction of normal cytokinesis: at the start of M phase, the nuclear envelope dissolves, chromatin undergoes condensation, chromosomes pair and then separate, two new nuclear envelopes form, and cytokinesis is completed. b Chromosomal Disjunction: during chromosomal separation, one or more chromosomes are not attached. As a result, the two daughter cells have unequal distribution of chromosomes following cytokinesis. This mechanism is generally thought to be the main cause of aneuploidy. c Nuclear envelope defect causes aneuploidy: We reason that loss of a nuclear envelope structural component such as lamin A/C results in a misshapen nucleus. Additionally, the lamin A/C-deficient cells frequently fail to complete cytokinesis. Thus, tetraploid cells and subsequently aneuploid cells are generated. Formation of micronuclei at G-phases is another mechanism for the loss of individual chromosomes. Thus, we propose that the nuclear envelope defect is the main cause of aneuploidy in ovarian cancer development

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Sylvester Comprehensive Cancer Center/University of Miami
(2)
Department of Cell Biology, University of Miami Miller School of Medicine
(3)
Institute of Biomedical Sciences, Laboratory of Biochemistry and Molecular Biology, University of Abomey-Calavi

Reference

  1. Capo-chichi CD, Yeasky TM, Smith ER, Xu XX. Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis. BMC Cell Biol. 17:37. DOI: 10.1186/s12860-016-0114-8.

Copyright

© The Author(s). 2016

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