Nuclear function and transport

  1. Research article

    Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression

    Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural...

    Elizabeth R. Smith, Yue Meng, Robert Moore, Jeffrey D. Tse, Arn G. Xu and Xiang-Xi Xu

    BMC Cell Biology 2017 18:8

    Published on: 14 January 2017

  2. Research article

    Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis

    The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is exte...

    Callinice D. Capo-chichi, Toni M. Yeasky, Elizabeth R. Smith and Xiang-Xi Xu

    BMC Cell Biology 2016 17:37

    Published on: 22 November 2016

    The Erratum to this article has been published in BMC Cell Biology 2017 18:1

  3. Research article

    Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells

    To explore the relationship between spatial genome organization and gene expression in the interphase nucleus, we used a genomic imprinting model, which offers parental-specific gene expression. Using 3D FISH ...

    Yvette Lahbib-Mansais, Harmonie Barasc, Maria Marti-Marimon, Florence Mompart, Eddie Iannuccelli, David Robelin, Juliette Riquet and Martine Yerle-Bouissou

    BMC Cell Biology 2016 17:35

    Published on: 1 October 2016

  4. Research

    High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division

    Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. ...

    David Dickerson, Marek Gierliński, Vijender Singh, Etsushi Kitamura, Graeme Ball, Tomoyuki U. Tanaka and Tom Owen-Hughes

    BMC Cell Biology 2016 17:33

    Published on: 8 September 2016

  5. Research article

    Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody

    Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is prese...

    Ian Holt, Nguyen Thuy Duong, Qiuping Zhang, Le Thanh Lam, Caroline A. Sewry, Kamel Mamchaoui, Catherine M. Shanahan and Glenn E. Morris

    BMC Cell Biology 2016 17:26

    Published on: 27 June 2016

  6. Research article

    Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals

    Ankyrin repeats and LEM domain containing protein 1 (Ankle1) belongs to the LEM protein family, whose members share a chromatin-interacting LEM motif. Unlike most other LEM proteins, Ankle1 is not an integral ...

    Livija Zlopasa, Andreas Brachner and Roland Foisner

    BMC Cell Biology 2016 17:23

    Published on: 1 June 2016

  7. Research article

    The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions

    The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a r...

    Donatella Ponti, Daniela Bastianelli, Paolo Rosa, Luca Pacini, Mohsen Ibrahim, Erino Angelo Rendina, Giuseppe Ragona and Antonella Calogero

    BMC Cell Biology 2015 16:27

    Published on: 17 November 2015

  8. Research article

    BORIS/CTCFL is an RNA-binding protein that associates with polysomes

    BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched ...

    Babatunji W Ogunkolade, Tania A Jones, Johan Aarum, Jaroslaw Szary, Nicholas Owen, Diego Ottaviani, Muhammad A Mumin, Shyam Patel, Christopher A Pieri, Andrew R Silver and Denise Sheer

    BMC Cell Biology 2013 14:52

    Published on: 26 November 2013

  9. Research article

    Yeast importin-β is required for nuclear import of the Mig2 repressor

    Mig2 has been described as a transcriptional factor that in the absence of Mig1 protein is required for glucose repression of the SUC2 gene. Recently it has been reported that Mig2 has two different subcellular l...

    Alejandra Fernández-Cid, Montserrat Vega, Pilar Herrero and Fernando Moreno

    BMC Cell Biology 2012 13:31

    Published on: 6 November 2012

  10. Research article

    Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells

    MeCP2 (CpG-binding protein 2) is a nuclear multifunctional protein involved in several cellular processes, like large-scale chromatin reorganization and architecture, and transcriptional regulation. In recent ...

    Federica Babbio, Ilaria Castiglioni, Chiara Cassina, Marzia Bruna Gariboldi, Christian Pistore, Elena Magnani, Gianfranco Badaracco, Elena Monti and Ian Marc Bonapace

    BMC Cell Biology 2012 13:19

    Published on: 11 July 2012

  11. Research article

    Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells

    Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma derived from skeletal muscle precursor cells, which accounts for 5-8% of all childhood malignancies. Disseminated RMS represents a major clinical obsta...

    Steven J Wolf, Tony Huynh, Nicole S Bryce, Trevor W Hambley, Laurence PG Wakelin, Bernard W Stewart and Daniel R Catchpoole

    BMC Cell Biology 2011 12:36

    Published on: 24 August 2011