Cytoplasmic and organelle biology

Section edited by Andrew Peden

This section will consider submissions with a focus on the structure and function of the cellular organelles, cytoplasm and membrane trafficking.

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  1. Research article

    Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila

    In Drosophila early post-meiotic spermatids, mitochondria undergo dramatic shaping into the Nebenkern, a spherical body with complex internal structure that contains two interwrapped giant mitochondrial derivativ...

    Eric M. Sawyer, Elizabeth C. Brunner, Yihharn Hwang, Lauren E. Ivey, Olivia Brown, Megan Bannon, Dennis Akrobetu, Kelsey E. Sheaffer, Oshauna Morgan, Conroy O. Field, Nishita Suresh, M. Grace Gordon, E. Taylor Gunnell, Lindsay A. Regruto, Cricket G. Wood, Margaret T. Fuller…

    BMC Cell Biology 2017 18:16

    Published on: 23 March 2017

  2. Methodology article

    Hierarchical imaging: a new concept for targeted imaging of large volumes from cells to tissues

    Imaging large volumes such as entire cells or small model organisms at nanoscale resolution seemed an unrealistic, rather tedious task so far. Now, technical advances have lead to several electron microscopy (...

    Irene Wacker, Waldemar Spomer, Andreas Hofmann, Marlene Thaler, Stefan Hillmer, Ulrich Gengenbach and Rasmus R. Schröder

    BMC Cell Biology 2016 17:38

    Published on: 12 December 2016

  3. Research article

    Extra-renal locations of the a4 subunit of H+ATPase

    Vacuolar-type proton pumps help maintain acid–base homeostasis either within intracellular compartments or at specialised plasma membranes. In mammals they are made up of 13 subunits, which form two functional...

    Zoe J. Golder and Fiona E. Karet Frankl

    BMC Cell Biology 2016 17:27

    Published on: 2 July 2016

  4. Research article

    Myc-binding protein orthologue interacts with AKAP240 in the central pair apparatus of the Chlamydomonas flagella

    Flagella and cilia are fine thread-like organelles protruding from cells that harbour them. The typical ‘9 + 2’ cilia confer motility on these cells. Although the mechanistic details of motility remain elusive...

    Venkatramanan G. Rao, Ruhi B. Sarafdar, Twinkle S. Chowdhury, Priyanka Sivadas, Pinfen Yang, Prabhakar M. Dongre and Jacinta S. D’Souza

    BMC Cell Biology 2016 17:24

    Published on: 10 June 2016

  5. Research article

    Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1pΔNterm only in combination with Ldb16p

    Seipin is required for the correct assembly of cytoplasmic lipid droplets. In the absence of the yeast seipin homolog Sei1p (formerly Fld1p), droplets are slow to bud from the endoplasmic reticulum, lack the n...

    Sungwon Han, Derk D. Binns, Yu-Fang Chang and Joel M. Goodman

    BMC Cell Biology 2015 16:29

    Published on: 4 December 2015

  6. Research article

    Signal dependent ER export of lemur tyrosine kinase 2

    The membrane anchored kinase, LMTK2, is a serine/threonine kinase predominantly localized to endosomal compartments. LMTK2 has been shown to be involved in the trafficking of the CFTR ion channel, the androgen...

    E. C. Butler and Neil A. Bradbury

    BMC Cell Biology 2015 16:26

    Published on: 11 November 2015

  7. Research article

    Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage

    Lipids are stored within cells in lipid droplets (LDs). They consist of a core of neutral lipids surrounded by a monolayer of phospholipids, predominantly phosphatidylcholine (PC). LDs are very dynamic and can...

    Christine Moessinger, Kristina Klizaite, Almut Steinhagen, Julia Philippou-Massier, Andrej Shevchenko, Michael Hoch, Christer S Ejsing and Christoph Thiele

    BMC Cell Biology 2014 15:43

    Published on: 10 December 2014

  8. Methodology article

    A morphologic and semi-quantitative technique to analyze synthesis and release of specific proteins in cells

    With the rapid advancement of cell biology, the evaluation of a given protein’s synthesis and release in cells becomes critical. However, up to now there has been no technique available to morphologically visu...

    Guowei Huang, Yun Wang, Juping Wang, Chunzhang Yang, Tao Huang, Zhengping Zhuang and Jiang Gu

    BMC Cell Biology 2014 15:45

    Published on: 5 December 2014

  9. Research article

    A role for Rab27 in neutrophil chemotaxis and lung recruitment

    Neutrophils are a critical part of the innate immune system. Their ability to migrate into infected or injured tissues precedes their role in microbial killing and clearance. We have previously shown that Rab2...

    Rajesh K Singh, Rebecca C Furze, Mark A Birrell, Sara M Rankin, Alistair N Hume and Miguel C Seabra

    BMC Cell Biology 2014 15:39

    Published on: 31 October 2014

  10. Research article

    Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism

    The expression of 2′-5′-Oligoadenylate synthetases (OASs) is induced by type 1 Interferons (IFNs) in response to viral infection. The OAS proteins have a unique ability to produce 2′-5′ Oligoadenylates, which ...

    Karina Hansen Kjær, Jytte Pahus, Mariann Fagernæs Hansen, Jesper Buchhave Poulsen, Erik Ilsø Christensen, Just Justesen and Pia Møller Martensen

    BMC Cell Biology 2014 15:33

    Published on: 9 September 2014

  11. Research article

    IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis

    The Akita mutation (C96Y) in the insulin gene results in early onset diabetes in both humans and mice. Expression of mutant proinsulin (C96Y) causes endoplasmic reticulum (ER) stress in pancreatic β-cells and ...

    Liling Zhang, Courtney Nosak, Pietro Sollazzo, Tanya Odisho and Allen Volchuk

    BMC Cell Biology 2014 15:29

    Published on: 10 July 2014

  12. Review

    Recent advances in live cell imaging of hepatoma cells

    Live cell imaging enables the study of dynamic processes of living cells in real time by use of suitable reporter proteins and the staining of specific cellular structures and/or organelles. With the availabil...

    Sandeep Salipalli, Prafull Kumar Singh and Jürgen Borlak

    BMC Cell Biology 2014 15:26

    Published on: 8 July 2014

  13. Research article

    Clathrin expression in Trypanosoma cruzi

    Clathrin-mediated vesicular trafficking, the mechanism by which proteins and lipids are transported between membrane-bound organelles, accounts for a large proportion of import from the plasma membrane (endocy...

    Ligia Cristina Kalb, Yohana Camila Antunes Frederico, Cassiano Martin Batista, Iriane Eger, Stênio Perdigão Fragoso and Maurilio José Soares

    BMC Cell Biology 2014 15:23

    Published on: 19 June 2014

  14. Research article

    Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

    Upon activation neutrophil releases microparticles - small plasma membrane vesicles that contain cell surface proteins and cytoplasmic matter, with biological activities. In this study we investigated the pote...

    Thassila Nogueira Pitanga, Luciana de Aragão França, Viviane Costa Junqueira Rocha, Thayna Meirelles, Valéria Matos Borges, Marilda Souza Gonçalves, Lain Carlos Pontes-de-Carvalho, Alberto Augusto Noronha-Dutra and Washington Luis Conrado dos-Santos

    BMC Cell Biology 2014 15:21

    Published on: 11 June 2014

  15. Research article

    Tissue specific expression of Myosin IC Isoforms

    Myosin IC is a single headed member of the myosin superfamily that localizes to the cytoplasm and the nucleus and is implicated in a variety of processes in both compartments. We recently identified a novel is...

    Neil L Sielski, Ivanna Ihnatovych, Jacob J Hagen and Wilma A Hofmann

    BMC Cell Biology 2014 15:8

    Published on: 11 March 2014

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