Cell differentiation and proliferation

This section will consider submissions with a focus on cell culture, growth and differentiation, including stem and germ cells, multipotency and tumor invasion.

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  1. Research article

    Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation

    Biomaterials are widely used to regenerate or substitute bone tissue. In order to evaluate their potential use for clinical applications, these need to be tested and evaluated in vitro with cell culture models...

    Raquel Núñez-Toldrà, Ester Martínez-Sarrà, Carlos Gil-Recio, Miguel Ángel Carrasco, Ashraf Al Madhoun, Sheyla Montori and Maher Atari

    BMC Cell Biology 2017 18:21

    Published on: 21 April 2017

  2. Research article

    Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts

    External root resorption, commonly starting from cementum, is a severe side effect of orthodontic treatment. In this pathological process and repairing course followed, cementoblasts play a significant role. P...

    Yuyu Li, Zhiai Hu, Chenchen Zhou, Yang Xu, Li Huang, Xin Wang and Shujuan Zou

    BMC Cell Biology 2017 18:19

    Published on: 20 April 2017

  3. Research article

    Mesenchymal stem cells and myoblast differentiation under HGF and IGF-1 stimulation for 3D skeletal muscle tissue engineering

    Volumetric muscle loss caused by trauma or after tumour surgery exceeds the natural regeneration capacity of skeletal muscle. Hence, the future goal of tissue engineering (TE) is the replacement and repair of ...

    R. Witt, A. Weigand, A. M. Boos, A. Cai, D. Dippold, A. R. Boccaccini, D. W. Schubert, M. Hardt, C. Lange, A. Arkudas, R. E. Horch and J. P. Beier

    BMC Cell Biology 2017 18:15

    Published on: 28 February 2017

  4. Research article

    Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties

    Cell-based therapy is a treatment method in tendon injuries. Bone morphogenic protein 12 (BMP-12) possesses tenogenic activity and was proposed as a differentiating factor for stem cells directed to transplant...

    Weronika Zarychta-Wiśniewska, Anna Burdzinska, Agnieszka Kulesza, Kamila Gala, Beata Kaleta, Katarzyna Zielniok, Katarzyna Siennicka, Marek Sabat and Leszek Paczek

    BMC Cell Biology 2017 18:13

    Published on: 18 February 2017

  5. Research article

    Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities

    Dental pulp stem cells (DPSCs) are increasingly being recognized as a viable cell source for regenerative medicine. Although significant variations in their ex vivo expansion are well-established, DPSC prolife...

    Amr Alraies, Nadia Y. A. Alaidaroos, Rachel J. Waddington, Ryan Moseley and Alastair J. Sloan

    BMC Cell Biology 2017 18:12

    Published on: 2 February 2017

  6. Research article

    Nuclear and structural dynamics during the establishment of a specialized effector-secreting cell by Magnaporthe oryzae in living rice cells

    To cause an economically important blast disease on rice, the filamentous fungus Magnaporthe oryzae forms a specialized infection structure, called an appressorium, to penetrate host cells. Once inside host cells...

    Emma N. Shipman, Kiersun Jones, Cory B. Jenkinson, Dong Won Kim, Jie Zhu and Chang Hyun Khang

    BMC Cell Biology 2017 18:11

    Published on: 26 January 2017

  7. Methodology article

    Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction

    Karyotypic integrity is essential for the successful germline transmission of alleles mutated in embryonic stem (ES) cells. Classical methods for the identification of aneuploidy involve cytological analyses t...

    Gemma F. Codner, Loic Lindner, Adam Caulder, Marie Wattenhofer-Donzé, Adam Radage, Annelyse Mertz, Benjamin Eisenmann, Joffrey Mianné, Edward P. Evans, Colin V. Beechey, Martin D. Fray, Marie-Christine Birling, Yann Hérault, Guillaume Pavlovic and Lydia Teboul

    BMC Cell Biology 2016 17:30

    Published on: 5 August 2016

  8. Methodology article

    Extended 2D myotube culture recapitulates postnatal fibre type plasticity

    The traditional problems of performing skeletal muscle cell cultures derived from mammalian or avian species are limited myotube differentiation, and transient myotube persistence which greatly restricts the a...

    Sujith Sebastian, Leah Goulding, Suresh V. Kuchipudi and Kin-Chow Chang

    BMC Cell Biology 2015 16:23

    Published on: 17 September 2015

  9. Research article

    MicroRNA-34a inhibits human trophoblast cell invasion by targeting MYC

    Preeclampsia, one of the major disorders of pregnancy, is characterized by inadequate trophoblast invasion and defective trophoblast-mediated remodeling of placental vasculature. MicroRNA-34a (miR-34a) has bee...

    Manni Sun, Haiying Chen, Jing Liu, Chunxiao Tong and Tao Meng

    BMC Cell Biology 2015 16:21

    Published on: 3 September 2015

  10. Research article

    Three-dimensional poly-(ε-caprolactone) nanofibrous scaffolds directly promote the cardiomyocyte differentiation of murine-induced pluripotent stem cells through Wnt/β-catenin signaling

    Environmental factors are important for stem cell lineage specification, and increasing evidence indicates that the nanoscale geometry/topography of the extracellular matrix (ECM) directs stem cell fate. Recen...

    Yan Chen, Di Zeng, Lu Ding, Xiao-Li Li, Xiong-Tao Liu, Wen-Ju Li, Ting Wei, Song Yan, Jiang-Hui Xie, Li Wei and Qiang-Sun Zheng

    BMC Cell Biology 2015 16:22

    Published on: 3 September 2015

  11. Research article

    Gene expression and protein secretion during human mesenchymal cell differentiation into adipogenic cells

    Mesenchymal stromal cells (MSC) can be obtained from potentially any tissue from the human body, but cells purified from different sources are undoubtedly different, and for each medical application, the MSC w...

    Paola Romina Amable, Marcus Vinicius Telles Teixeira, Rosana Bizon Vieira Carias, José Mauro Granjeiro and Radovan Borojevic

    BMC Cell Biology 2014 15:46

    Published on: 20 December 2014

  12. Methodology

    A thin layer angiogenesis assay: a modified basement matrix assay for assessment of endothelial cell differentiation

    Basement matrices such as Matrigel™ and Geltrex™ are used in a variety of cell culture assays of anchorage-dependent differentiation including endothelial cell tube formation assays. The volumes of matrix reco...

    Ashton Faulkner, Robert Purcell, Andrew Hibbert, Sally Latham, Scott Thomson, Wendy L Hall, Caroline Wheeler-Jones and David Bishop-Bailey

    BMC Cell Biology 2014 15:41

    Published on: 5 December 2014

  13. Methodology article

    Isolation and epithelial co-culture of mouse renal peritubular endothelial cells

    Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated...

    Ye Zhao, Hong Zhao, Yun Zhang, Tania Tsatralis, Qi Cao, Ya Wang, Yiping Wang, Yuan Min Wang, Steve I Alexander, David C Harris and Guoping Zheng

    BMC Cell Biology 2014 15:40

    Published on: 30 November 2014

  14. Research article

    Cell specific apoptosis by RLX is mediated by NFκB in human colon carcinoma HCT-116 cells

    Resistance to chemotherapy represents a major obstacle in correcting colorectal carcinomas (CRC). Inspite of recent advances in the treatment of metastatic disease, the prognosis of the patients remains poor. ...

    Asif Khurshid Qazi, Aashiq Hussain, Mushtaq A Aga, Shakir Ali, Subhash Chandra Taneja, Parduman Raj Sharma, Ajit Kumar Saxena, Dilip M Mondhe and Abid Hamid

    BMC Cell Biology 2014 15:36

    Published on: 10 October 2014

  15. Research article

    Physalis angulata induces in vitro differentiation of murine bone marrow cells into macrophages

    The bone marrow is a hematopoietic tissue that, in the presence of cytokines and growth factors, generates all of the circulating blood cells. These cells are important for protecting the organism against path...

    Bruno José Martins da Silva, Ana Paula D Rodrigues, Luis Henrique S Farias, Amanda Anastácia P Hage, Jose Luiz M Do Nascimento and Edilene O Silva

    BMC Cell Biology 2014 15:37

    Published on: 3 October 2014

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